Correlation between NT-proBNP and heart functions in patients with chronic heart failure under different levels of glomerular filtration rate
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摘要: 目的:研究慢性心功能不全患者N末端脑钠肽前体(NT-proBNP)和心功能状态在肾小球滤过率(GFR)不同范围内的相关性。方法:连续选择200例慢性心功能不全患者,在病情稳定情况下检测NT-proBNP、血清肌酐水平,评价纽约心功能分级(NYHA),计算GFR。结果:NT-proBNP和NYHA随GFR降低而增加,左室射血分数(LVEF)随GFR降低而降低(均P<0.05);左室舒张末期内径(LVEDd)在不同范围GFR内差异无统计学意义。在GFR水平>45 ml/min时,NT-proBNP与NYHA呈正相关,与LVEF呈负相关,与LVEDd无明显相关;在GFR水平<45 ml/min时,NT-proBNP与NYHA、LVEF和LVEDd均无明显相关性。结论:慢性心功能不全患者NT-proBNP和心功能状态的关系需考虑不同的肾小球滤过率范围。Abstract: Objective: To study the relationship between NT-proBNP and heart functions in patients with chronic heart failure under different levels of glomerular filtration rate (GFR). Method: A total of 120 consecutives was enrolled, serum NT-proBNP and creatinine levels were measured, New York Heart Association (NYHA) classes was evaluated, and creatinine clearance rate (GFR) was calculated. Result: NT-proBNP and NYHA were higher as GFR was lowing, LVEF was lowing as GFR was lowing(P<0.05), LVEDd was no statistical differences in different GFR ranges. NT-proBNP was positive with NYHA and negative with LVEF when GFR>45 ml/min, while, NT-proBNP was non-related to LVEDd. NT-proBNP and NYHA, LVEF, LVEDd were no correlation when GFR <45 ml/min.Conclusion: The relationship between NT-proBNP and heart functions in patients with chronic heart failure should consider different levels of glomerular filtration rate.
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