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摘要: 冠状动脉微循环障碍(CMVO)对急性心肌梗死(AMI)再灌注后临床获益和远期预后有明显影响。CMVO的发病机制和诊治策略目前尚不十分明确。本文综述了近几年来AMI患者CMVO最新的研究机制和诊断进展,并总结了不同临床背景下的个体化治疗策略。Abstract: Coronary microvascular obstruction (CMVO) contributes to obvious harmful impact on clinical benefit and long-term prognosis of reperfusion after acute myocardial infarction (AMI). The pathogenesis and diagnosis-treatment schemes are not very definite yet. In this article, we have reviewed the latest research and diagnosis progresses in recent 10 years and summarized individualized treatment strategies in different clinical background.
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[1] CHEN C, WEI J, ALBADRI A, et al. Coronary microvascular dysfunction-epidemiology, pathogenesis, prognosis, diagnosis, risk factors and therapy[J]. Circ J, 2017, 81:3-11.
[2] NICCOLI G, SCALONE G, LERMAN A, et al. Coronary microvascular obstruction in acute myocardial infarction[J]. Eur Heart J, 2016, 37:1024-1033.
[3] REINSTADLER S J, STIERMAIER T, FUERNAU G, et al. The challenges and impact of microvascular injury in ST-elevation myocardial infarction[J]. Expert Rev Cardiovasc Ther, 2016, 14:431-443.
[4] ITO H. Etiology and clinical implications of microvascular dysfunction in patients with acute myocardial infarction[J]. Int Heart J, 2014, 55:185-189.
[5] MARINESCU M A, LOFFLER A I, OUELLETTE M, et al. Coronary microvascular dysfunction, microvascular angina, and treatment strategies[J]. JACC Cardiovasc Imaging, 2015, 8:210-220.
[6] LOFFLER A I, BOURQUE J M. Coronary microvascular dysfunction, microvascular angina, and management[J]. Curr Cardiol Rep, 2016, 18:1.
[7] KIM J S, KIM J, CHOI D, et al. Efficacy of high-dose atorvastatin loading before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction:the STATIN STEMI trial[J]. JACC Cardiovasc Interv, 2010, 3:332-339.
[8] VLAAR P J, SVILAAS T, VAN DER HORST I C, et al. Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS):a 1-year follow-up study[J]. Lancet, 2008, 371:1915-1920.
[9] CARRICK D, OLDROYD K G, MCENTEGART M, et al. A randomized trial of deferred stenting versus immediate stenting to prevent no-or slow-reflow in acute ST-segment elevation myocardial infarction (DEFER-STEMI)[J]. J Am Coll Cardiol, 2014, 63:2088-2098.
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