微小RNA在心肌梗死再生修复中的研究进展

王宁; 文平; 刘辉

doi:10.13201/j.issn.1001-1439.2017.08.002

微小RNA在心肌梗死再生修复中的研究进展

- 1 大连市儿童医院心脏中心(辽宁大连, 116012);
- 2 临汾市第四人民医院心脏大血管外科(山西临汾, 041000)

详细信息

通讯作者: 刘辉,E-mail:sdcocowangning@163.com

中图分类号: R542.2

收稿日期: 2017-02-25

Research progress of microRNAs in the regeneration and repair after myocardial infarction

- 1 Department of Cardiovascular Surgery, Dalian Children's Hospital, Dalian Medical University, Da'lian, Liaoning, 116012, China;
- 2 Department of Cardiovascular Surgery, The Fourth People's Hospital, linfen, Shanxi, 041000, China

More Information

Corresponding author: LIU Hui, E-mail: sdcocowangning@163.com

Received Date: 25 February 2017

摘要

摘要: 微小RNA(micro RNAs,miRs)是一类具有调控功能的内源性非编码RNA。心肌梗死是导致心脏重构和慢性心力衰竭的常见心血管事件,诸多miRs被发现在心肌梗死的病理生理机制中发挥重要作用,而心肌梗死后的心脏再生亦受到miRs调控。miRs参与调控心脏干、祖细胞对心肌的保护效应,并可诱导成纤维细胞向心肌细胞的重编程。此外,miRs可调节缺血后的血管生成,并参与不同细胞之间的细胞通讯。本文总结了miRs在上述研究中的最新进展,并讨论了miRs应用于心肌梗死再生修复中的前景和局限性。
- 微小RNA /
- 心肌梗死 /
- 再生 /
- 血管生成
Abstract: MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression. Myocardial infarction is a common cardiovascular event that results in cardiac remodeling and subsequent chronic heart failure. Several miRs have been reported to regulate important pathophysiological processes that lead to the consequences of myocardial infarction. Cardiac regeneration can also be regulated by miRs that interfere with cardioprotective effects mediated by stem or progenitor cells. miRs can also be used for direct reprogramming of cardiac fibroblasts into cardiomyocytes. Besides, miRs can regulate postischaemic angiogenesis and be transported via communication between cells of various types. In this review, we focus on the current understanding of the roles of miRs in these processes and particularly discuss the therapeutic potential and limitations of miRs in rendering cardiac regeneration and repair after myocardial infarction.
- microRNA /
- myocardial infaction /
- regeneration /
- angiogenesis

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