Correlation study of mCRP,GAS and severity of coronary artery lesions in patients with acute ST segment elevation myocardial infarction
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摘要: 目的:探讨急性ST段抬高型心肌梗死(STEMI)患者血浆单体C-反应蛋白(mCRP)水平、整体面积应变(GAS)与冠状动脉(冠脉)病变程度的相关性。方法:选取就诊于我院心内科的180例患者,分为STEMI组150例和对照组30例。其中STEMI组依据Gensini积分分为:轻度组(0<积分≤40)、中度组(40<积分<80)和重度组(积分≥80)。分析血浆mCRP水平及左室射血分数(LVEF)值、GAS值在各组间的差异,Pearson相关分析研究mCRP水平、GAS值与Gensini积分的相关性。结果:① STEMI组患者血浆mCRP水平显著高于对照组(P<0.05),STEMI组各亚组间差异亦有统计学意义(P<0.05);STEMI组GAS值低于对照组(P<0.05),各亚组间差异亦有统计学意义(P<0.05)。② mCRP水平与Gensini积分正相关(r=0.672,P<0.05),GAS值与Gensini积分呈负相关(r=-0.56,P<0.05)。结论:mCRP水平、GAS与STEMI冠脉病变严重程度密切相关,提示mCRP水平联合GAS可以早期、无创评估STEMI病情严重程度。
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关键词:
- 急性ST段抬高型心肌梗死 /
- 单体C-反应蛋白 /
- 左室射血分数 /
- 整体面积应变 /
- 冠状动脉病变程度
Abstract: Objective:To investigate the relationship between plasma level of monomeric C-reactive protein (mCRP) and global area strain (GAS) in patients with acute ST segment elevation myocardial infarction (STEMI).Method:One-hundred and eighty patients in our hospital were divided into control group of 30 cases and 150 cases of myocardial infarction group.Myocardial infarction group was further divided into mild group (0<score ≤ 40), moderate group (40<score<80) and severe group (score ≥ 80) according to Gensini score.We analysed the differences of plasma mCRP level, LVEF value, and GAS value between the groups.We also performed pearson correlation analysis of mCRP level, GAS value and Gensini correlation.Result:① The plasma mCRP activity in patients of ST segment elevation myocardial infarction was significantly higher than that in the control group (P<0.05);there was also significant difference of mCRP activity among the groups of myocardial infarction (P<0.05);GAS of the segment elevation myocardial infarction group GAS were lower than that of control group (P<0.05);there was also significant difference of GAS among the groups of myocardial infarction (P<0.05). ② mCRP level was positively correlated with Gensini score (r=0.672, P<0.05), and GAS value was negatively correlated with Gensini score (r=-0.56, P<0.05). Conclusion:The level of mCRP and GAS were closely correlated with the severity of coronary artery lesions in STEMI, suggesting that mCRP level combined with GAS can be used to evaluate the severity of STEMI early and non-invasively. -
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