环状RNA:心血管疾病新型标志物

王晓燕; 邹云增

doi:10.13201/j.issn.1001-1439.2017.11.024

环状RNA:心血管疾病新型标志物

王晓燕^1,2,
邹云增^1,2, ,

- 1 复旦大学附属中山医院心血管内科(上海, 200032);
- 2 上海市心血管研究所
基金项目:
国家自然科学基金重点项目 (No:30930043)

详细信息

通讯作者: 邹云增, E-mail:zou.yunzeng@zs-hospital.sh.cn

中图分类号: R54

收稿日期: 2017-08-15

Circular RNA:Biomarker of cardiovascular disease

WANG Xiaoyan^1,2,
ZOU Yunzeng^1,2, ,

- 1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China;
- 2 Cardiovascular Institute in Shanghai

More Information

Corresponding author: ZOU Yunzeng, E-mail: zou.yunzeng@zs-hospital.sh.cn

Received Date: 15 August 2017

摘要

摘要: 环状RNA是新型非编码RNA, 可以"海绵分子"的形式结合microRNA和相关蛋白, 参与心血管疾病的调控。环状RNA广泛存在于细胞内或细胞外, 包括血液、唾液和精液, 提示环状RNA或可作为心血管疾病的新型治疗靶点和生物标记物。本文对环状RNA的产生机制和表达特征、环状RNA与心血管疾病的关系、环状RNA作为新型生物标记物和治疗靶点的可能性进行综述。
- 环状RNA /
- 心血管疾病 /
- 生物标记物
Abstract: Circular RNAs (circRNAs) as a class of newly discovered endogenous noncoding RNAs, have been implicated in the evolution of CVD by sponge-like regulation of microRNAs and proteins, indicating that circRNAs are promising therapy targets and potential biomarkers for CVD.In this review, we characterize the biogenesis and expression of circular RNA, highlight the regulatory role of circular RNA in different models of CVD.We also present perspectives of circular RNAs as novel biomarkers and therapeutic targets for the treatment of CVD.
- circular RNA /
- cardiovascular disease /
- biomarker

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