血清补体C1q水平与老年患者冠状动脉狭窄程度的相关性研究

匡圆圆; 马琦琳; 张赛丹

doi:10.13201/j.issn.1001-1439.2018.11.010

血清补体C1q水平与老年患者冠状动脉狭窄程度的相关性研究

- 中南大学湘雅医院心内科(长沙, 410008)
基金项目:
国家自然科学基金面上项目 (No:81370250)

湖南省科技厅课题 (No:2017SK50108)

详细信息

通讯作者: 马琦琳,E-mail:mqilin2004@163.com

中图分类号: R541.4

收稿日期: 2018-07-16

Relationship between serum complement C1q and severity of coronary artery disease in the elderly

- Department of Cardiology, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China

More Information

Corresponding author: MA Qilin, E-mail: mqilin2004@163.com

Received Date: 16 July 2018

摘要

摘要: 目的:探讨血清补体C1q水平与老年患者冠状动脉(冠脉)狭窄程度的相关性。方法:采用前瞻性研究,连续选取2017-12-01-2018-05-31首次于中南大学湘雅医院心内科住院且≥65岁的冠心病患者214例,入院后采用免疫透射比浊法测定其血清补体C1q水平,并完善冠脉造影,进行Gensini评分,按照评分分为轻度(0分≤X<18分)、中度(18分≤X<41分)、重度组(X≥41分)。采用多元线性回归分析、多因素Logistic回归分析及ROC曲线研究血清补体C1q与老年患者冠脉狭窄程度之间的相关性。结果:与轻度组相比,中、重度组高密度脂蛋白胆固醇(HDL-C)及左室射血分数(LVEF)明显下降(均P<0.05),三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)、糖化血红蛋白(HbAlc)、C1q及左心室舒张末期内径(LVEDd)明显上升(均P<0.05)。相关性分析显示,血清补体C1q与冠脉狭窄程度呈显著正相关(r=0.018,P<0.05),是冠脉狭窄程度的独立预测因子(OR=1.071,95%CI:1.046~1.096,P<0.05)。ROC曲线分析显示,血清补体C1q水平>172.75 mg/L的敏感度和特异度分别为89.5%和82.0%,曲线下面积为0.920,具有较好的诊断效能。结论:血清补体C1q作为一种简单、廉价的临床血清学指标,对老年患者冠脉狭窄程度有较好的评估、诊断价值。
- 补体C1q /
- 冠状动脉狭窄 /
- 多元线性回归 /
- Logistic回归分析 /
- ROC工作曲线
Abstract: Objective:To analyze the relationship between serum complement C1q and severity of coronary artery stenosis in elderly patients.Method:A total of 214 patients (≥65 years old) who were hospitalied in Xiangya Hospital firstly and diagnosed as coronary artery disease were enrolled.After admission,the serum complement C1q level was determined by immunoturbidimetric assay.Patients were divided into three groups according to the Gensini score:Quartile 1 (0≤X<18) (n=56),Quartile 2 (18≤X<41) (n=44) and Quartile 3 (X≥41) (n=114).Multiple linear regression analysis,Logistic regression and receiver operating characteristic curve were used to evaluate the relationship of serum complement C1q and severity of coronary artery stenosis.Result:Compared with Quartile 1,levels of HDL-C and LVEF in Quartile 2 and Quartile 3 were significantly decreased,while TG,TC,LDL-C,hs-CRP,HbAlc,C1q and LVEDd were increased (all P<0.05).The correlation analysis showed that the serum complement C1q was positively related to the severity of coronary artery stenosis (r=0.018,P<0.05).C1q was an independent predictor of coronary stenosis (OR=1.071,95%CI:1.046-1.096,P<0.05).ROC curve showed that the sensitivity was 89.5% and the specificity was 82.0% when the cut off value was 172.75 mg/L,and the AUC was 0.920,prompting a good diagnostic efficacy.Conclusion:Serum complement C1q is a simple,economic and clinical serologic indicator,which has a good clinical value.
- serum complement C1q /
- coronary artery stenosis /
- multiple linear regression analysis /
- logistic re gression /
- ROC curve

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