基于CMR形变配准算法技术定量孤立性左室心肌致密化不全心肌应变的初步研究

刘佳; 崔越; 曹玉坤; 宋晶; 周皛月; 史河水

doi:10.13201/j.issn.1001-1439.2018.12.005

基于CMR形变配准算法技术定量孤立性左室心肌致密化不全心肌应变的初步研究

- 1 华中科技大学同济医学院附属协和医院放射科(武汉, 430022);
- 2 分子影像湖北省重点实验室;
- 3 西门子医疗系统有限公司

详细信息

通讯作者: 史河水,E-mail:heshuishi@hust.edu.cn

中图分类号: R542.2

收稿日期: 2018-09-03

Quantitation of myocardial deformation in patients with isolated left ventricular non-compaction based on cardiacvascular magnetic resonance deformation registration algorithm:apreliminary study

- 1 Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;
- 2 Hubei Province Key Laboratory of Molecular Imaging;
- 3 MR Collaboration, Siemens Healthcare Ltd.

More Information

Corresponding author: SHI Heshui, E-mail: heshuishi@hust.edu.cn

Received Date: 03 September 2018

摘要

摘要: 目的:探究应用心脏磁共振形变配准算法 (CMR-DRA) 技术定量评估孤立性左室心肌致密化不全 (iLVNC) 患者心肌形变的价值。方法:对27例iLVNC患者 (iLVNC组) 及30例健康志愿者 (对照组) 行1.5T心脏磁共振检查, 将短轴电影导入DRA应力分析软件, 半自动计算整体和节段性左室收缩峰值径向应力 (Err)、周向应力 (Ecc)、纵向应力 (Ell) 及收缩期、舒张早期、舒张晚期应力率。结果:iLVNC组的整体Ell、Err和Ecc值均低于对照组[Ell:(-11.0±3.8)%:(-14.3±1.8)%;Err:(24.7±9.3)%:(38.5±6.1)%;Ecc:(-12.1±4.9)%:(-16.6±1.4)%;P＜0.01];iLVNC组左室射血分数 (LVEF)、每搏输出量指数 (SVI) 及心指数 (CI) 值均低于对照组[LVEF:(42.6±14.9)%:(57.5±4.9)%;SVI:(28.1±8.9) ml·m^-2:(41.2±8.1) ml·m^-2;CI:(1.8±0.6) L·min^-1·m^-2:(2.6±0.5) L·min^-1·m^-2;P＜0.01];iLVNC组的LVEF ≥ 50%组Err值低于对照组[(31.8±3.6)%:(38.5±6.1)%, P＜0.05];左室16节段Err值均低于对照组 (P＜0.05), 间壁基底段、下侧壁基底段Ecc值与对照组无明显统计学差异, 其余14个节段Ecc值均低于对照组 (P＜0.05), 游离壁心尖段及中间段、间隔壁中间段Ell值均低于对照组 (P＜0.05)。心功能及形变参数与非致密节段数目 (NoNC) 均无明显相关性 (P＞0.05)。结论:CMR-DRA技术能够定量评估iLVNC患者的左室心肌形变特征, 并且径向应力能够较LVEF更敏感地检测到心肌功能的受损。
- 心脏磁共振成像 /
- 孤立性左室心肌致密化不全 /
- 形变配准算法 /
- 心肌形变
Abstract: Objective: To explore the value of cardiovascular magnetic resonance based on deformation registration algorithm (DRA) in quantitation of myocardium deformation in patients with isolated left ventricular noncompaction (iLVNC).Method: We recruited 27 iLVNC patients (iLVNC group) and 30 healthy volunteers to undergo cardiovascular magnetic resonance on a 1.5 T MR scanner.Myocardial deformation analysis was performed after cardiac cine data were imported into the strain analysis software based on DRA technique.Global and segmental strain of radial, circumferential and longitudinal direction and strain rate of systolic, early-diastole and late-diastole were semi-automatically calculated.Result: The global Ell, Err and Ecc value were lower in iLVNC group than those in control group[Ell:(-11.0±3.8)% vs. (-14.3±1.8)%;Err:(24.7±9.3)% vs (38.5±6.1)%;Ecc:(-12.1±4.9)% vs. (-16.6±1.4)%;P＜0.01 for all].Left ventricular ejection fration (LVEF), stroke volume index (SVI) and cardiac index (CI) value were lower in iLVNC group than those in control group[LVEF:(42.6±14.9)% vs. (57.5±4.9)%;SVI:(28.1±8.9) ml· m^-2 vs. (41.2±8.1) ml· m^-2;CI:(1.8±0.6) L·min^-1·m^-2 vs. (2.6±0.5) L·min^-1·m^-2;P＜0.01 for all].Err value in EF ≥ 50% group was lower than that in control group[(31.8±3.6)% vs (38.5±6.1)%, P＜0.05].Err values in all the 16 segments were lower than those in control group (P＜0.05 for all).No significant differences of Ecc values in the basal septum and basal inferoseptal segments were found between iLVNC group and control group (P＞0.05), and the other 14 segments in iLVNC group were lower than those in control group (P＜0.05 for all).Ell values in apical segment and middle segment of the free wall, and in middle segment of the septal wall were lower than those in control group (P＜0.05 for all).All cardiac function and myocardial deformation parameters had no significant correlation with the number of non-compacted segment (NoNC) (P＞0.05 for all).Conclusion: CMR-DRA technique is conducive to quantitative evaluate myocardial deformation in patients with iLVNC, and myocardial deformation permits earlier detection of LV functional impairment.
- cardiovascular magnetic resonance imaging /
- isolated left ventricular non-compaction /
- deformation registration algorithm /
- myocardial deformation

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