心脏磁共振特征组织追踪成像定量评价健康人群左心室心肌形变

陈秋智; 刘霞; 刘智; 陈松; 王菲瑶; 李春平; 李睿

doi:10.13201/j.issn.1001-1439.2018.12.006

心脏磁共振特征组织追踪成像定量评价健康人群左心室心肌形变

- 1 重庆大学附属肿瘤医院/重庆市肿瘤研究所/重庆市肿瘤医院, 教育部生物流变科学与技术重点实验室(重庆大学)(重庆, 400044);
- 2 川北医学院附属医院
基金项目:
国家自然科学基金项目 (No:81801674)

详细信息

通讯作者: 李睿,E-mail:ddtwg_nsmc@163.com

中图分类号: 542542.2

收稿日期: 2018-08-27

Quantitative assessment of Left Ventricular Myocardial Deformation by CMR-FT in Healthy Population:A Preliminary study

- 1 Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital& Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, 400044, China;
- 2 North Sichuan Medical College, Nanchong

More Information

Corresponding author: LI Rui, E-mail: ddtwg_nsmc@163.com

Received Date: 27 August 2018

摘要

摘要: 目的:探讨3.0T心脏磁共振 (CMR) 特征组织追踪成像 (FT) 测量中国汉族健康人群左心室心肌形变参数的可行性, 并分析年龄、性别对各应变参数的影响。方法:本研究共纳入健康志愿者53例。其中男27例, 女26例。随后每组纳入人群按照年龄分为青年、中年及老年3个亚组。所有纳入者均行3.0TCMR检查。分析、对比不同性别和不同年龄组人群左心室整体及局部的径向、周向及纵向峰值应变 (PS)、峰值收缩期应变率 (PSSR)、峰值舒张期应变率 (PDSR)。结果:其中, 女性整体周向PS、纵向PS、心基底段周向PS大于男性;男性整体周向PSSR及心中间段周向PSSR、纵向PSSR大于女性。分析不同年龄段心肌形变结果显示, 整体径向PS在男女性中老年组均明显高于中年组和青年组;女性组整体周向PS、周向PDSR老年组低于青年组。左心室整体径向、周向、纵向PS分别与部分心功能参数相关。结论:3.0TCMR-FT能客观地量化健康人群左心室心肌形变的相关参数, 且不同性别、不同年龄段心肌各形变参数也存在差异, 制定相应正常人群心肌形变参数范围需考虑性别及年龄的影响。
- 心脏磁共振 /
- 健康人群 /
- 心肌形变
Abstract: Objective: To investigate the feasibility of using 3.0 TCardiovascular Magnetic Resonance Feature tracking imaging to assess left ventricular myocardial deformation parameters in healthy Chinese Han population, and to analyze the effect of age and gender on each parameter.Method: This study enrolled 53 healthy participants.The 27 participants are male while another 26 are female.All participants underwent 3.0 TCMR.The aim of this study was to analyze the global and regional radial, circumferential and longitudinal Peak Strain (PS), Peak systolic strain rate (PSSR) and Peak diastolic strain rate (PDSR) of left ventricular for different sex and age groups.Result: Female's global circumferential PS and longitudinal PS, as well as Basal segment circumferential are higher than male.On the other hand, male's global circumferential PSSR, middle segment circumferential PSSR and longitudinal PSSR were higher.Analysis of myocardial deformation in different ages showed that the global radial PS was significantly higher in the older group than the middle and young groups regardless of male or female.The global circumferential PS and circumferential PDSR in female older group were lower than in the young group.The global radial, circumferential, longitudinal PS of the left ventricle were related with some heart function parameters.Conclusion: 3.0 T CMR-FT can objectively quantify left ventricular myocardial deformation parameters in healthy people.For different sex and age groups, the values for left ventricular myocardial deformation parameters are different.Establishing value range of left ventricular myocardial deformation for healthy populations should consider the effects of sex and age.
- cardiovascular magnetic resonance /
- healthy people /
- myocardial deformation

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参考文献(37)

[1]	Scatteia A, Baritussio A, Bucciarelli-Ducci C.Strain imaging using cardiac magnetic resonance[J].Heart Fail Rev, 2017, 22 (4):465-476.
[2]	史河水, 曹玉坤.磁共振评价左室心肌应变技术及其临床应用的研究进展[J].临床心血管病杂志, 2017, 33 (12):1135-1139.
[3]	Cho EJ, Park SJ, Yun HR, et al.Predicting Left Ventricular dysfunction after surgery in patients with chronic mitral regurgitation:assessment of myocardial deformation by 2-Dimensional multilayer speckle tracking echocardiography[J].Korean Circ J, 2016, 46 (2):213-221.
[4]	Buss S J, Breuninger K, Lehrke S, et al.Assessment of myocardial deformation with cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy[J].Eur Heart JCardiovasc Imaging, 2015, 16 (3):307-315.
[5]	黄冬梅, 张宇虹, 礼广森, 等.心肌分层应变技术评价不同心功能尿毒症患者左室纵向功能[J].临床心血管病杂志, 2018, 34 (3):231-234.
[6]	丁尚伟, 谢玉环, 张利荣, 等.斑点追踪成像技术评估不同年龄健康孕妇妊娠期左室心肌整体长轴应变的变化规律灣[J].临床心血管病杂志, 2017, 33 (12):1162-1166.
[7]	Orwat S, Diller GP, Kempny A, et al.Myocardial deformation parameters predict outcome in patients with repaired tetralogy of Fallot[J].Heart, 2016, 102 (3):209-215.
[8]	Wong DT, Leong DP, Weightman MJ, et al.Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction[J].Eur Radiol, 2014, 24 (6):1219-1228.
[9]	Zerhouni EA, Parish DM, Rogers WJ, et al.Heart:Tagging a method of myocardlal-A method for noninvasive assessment of myocardlal motion[J].Radiology, 1988, 169 (1):59-63.
[10]	Hor KN, Gottliebson WM, Carson C, et al.Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis[J].JACC Cardiovasc Imaging, 2010, 3 (2):144-151.
[11]	Ibrahim ESH.Myocardial tagging by cardiovascular magnetic resonance:evolution of techniques——pulse sequences, analysis algorithms, and applications[J].JCardiovasc Magn Reson, 2011, 13 (36):1-40.
[12]	Schuster A, Morton G, Hussain ST, et al.The intraobserver reproducibility of cardiovascular magnetic resonance myocardial feature tracking strain assessment is independent of field strength[J].Eur J Radiol, 2013, 82 (2):296-301.
[13]	Ceelen F, Hunter RJ, Boubertakh R, et al.Effect of atrial fibrillation ablation on myocardial function:insights from cardiac magnetic resonance feature tracking analysis[J].Int J Cardiovasc Imaging, 2013, 29 (8):1807-1817.
[14]	Hor KN, Gottliebson WM, Carson C, et al.Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis[J].JACC Cardiovasc Imaging, 2010, 3 (2):144-151.
[15]	Augustine D, Lewandowski AJ, Lazdam M, et al.Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers:comparison with tagging and relevance of gender[J].J Cardiovasc Magn Reson, 2013, 15 (8):1-10.
[16]	Williams LK, Urbano-Moral JA, Rowin EJ, et al.Velocity vector imaging in the measurement of left ventricular myocardial mechanics on cardiac magnetic resonance imaging:correlations with echocardiographically derived strain values[J].J Am Soc Echocardiogr, 2013, 26 (10):1153-1162.
[17]	Onishi T, Saha SK, Ludwig DR, et al.Feature tracking measurement of dyssynchrony from cardiovascular magnetic resonance cine acquisitions:comparison with echocardiographic speckle tracking[J].J Cardiovasc Magn Reson, 2013, 15 (95):1-8.
[18]	Marwick TH.Measurement of strain and strain rate by echocardiograph:ready for prime time[J].J Am Coll Cardiol, 2006, 47 (7):1313-1327.
[19]	Cerqueira MD, Weissman NJ, Dilsizian V, et al.Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart[J].Circulation, 2002, 105 (4):539-542.
[20]	Buss SJ, Emami M, Mereles D, et al.Longitudinal left ventricular function for prediction of survival in systemic light-chain amyloidosis[J].J Am Coll Cardiol, 2012, 60 (12):1067-1076.
[21]	Motoki H, Borowski AG, Shrestha K, et al.Incremental prognostic value of assessing left ventricular myocardial mechanics in patients with chronic systolic heart failure[J].J Am Coll Cardiol, 2012, 60 (20):2074-2081.
[22]	Mangion K, Clerfond G, McComb C, et al.Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 And 3.0T:associations of myocardial strain with myocardial region, age, and sex[J].J Magn Reson Imaging, 2016, 44 (5):1197-1205.
[23]	Vo HQ, Marwick TH, Negishi K.MRI-derived myocardial strain measures in normal subjects[J].JACCCardiovasc Imaging, 2018, 11 (2):196-205.
[24]	曹玉坤, 崔越, 曾文娟, 等.1.5T磁共振定量正常人左室心肌组织特性和心肌应变的初步研究[J].临床心血管病杂志, 2017, 33 (11):1077-1082.
[25]	Zemrak F, Ambale-Venkatesh B, Captur G, et al.Left atrial structure in relationship to age, sex, ethnicity, and cardiovascular risk factors:MESA (Multi-Ethnic Study of Atherosclerosis)[J].Circ Cardiovasc Imaging, 2017, 10 (2):1-8.
[26]	Moreira HT, Nwabuo CC, Armstrong AC, et al.Reference ranges and regional patterns of left ventricular strain and strain rate using two-dimensional speckletracking echocardiography in a healthy middle-aged black and white population:The CARDIA Study[J].JAm Soc Echocardiogr, 2017, 30 (7):647-658.
[27]	Maceira AM, Tuset-Sanchis L, López-Garrido M, et al.Feasibility and reproducibility of feature-trackingbased strain and strain rate measures of the left ventricle in different diseases and genders[J].J Magn Reson Imaging, 2018, 47 (5):1415-1425.
[28]	Schuster A, Stahnke VC, Unterberg-Buchwald C, et al.Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics:Intervendor agreement and considerations regarding reproducibility[J].Clin Radiol, 2015, 70 (9):989-998.
[29]	刘红, 杨丹, 罗勇, 等.特征追踪心脏磁共振技术测量汉族健康人群左心室心肌应变正常参考值的研究[J].四川大学学报 (医学版), 2016, 10 (4):599-604.
[30]	Lei X, Liu H, Han Y, et al.Reference values of cardiac ventricular structure and function by steady-state freeprocession MRI at 3.0 Tin healthy adult Chinese volunteers[J].J Magn Reson Imaging, 2017, 45 (6):1684-1692.
[31]	Nio AQX, St?hr EJ, Shave RE.Age-related differences in left ventricular structure and function between healthy men and women[J].Climacteric, 2017, 20 (5):476-483.
[32]	Petersen SE, Aung N, Sanghvi MM, et al.Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort[J].J Cardiovasc Magn Reson, 2017, 19 (1):1-18.
[33]	Taylor RJ, Moody WE, Umar F, et al.Myocardial strain measurement with feature-tracking cardiovascular magnetic resonance:normal values[J].Eur Heart JCardiovasc Imaging, 2015, 16 (8):871-881.
[34]	Andre F, Steen H, Matheis P, et al.Age-and genderrelated normal left ventricular deformation assessed by cardiovascular magnetic resonance feature tracking[J].J Cardiovasc Magn Reson, 2015, 17 (1):1-14.
[35]	Augustine D, Lewandowski AJ, Lazdam M, et al.Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers:comparison with tagging and relevance of gender[J].J Cardiovasc Magn Reson, 2013, 15 (8):1-10.
[36]	Cheng S, Fernandes VR, Bluemke DA, et al.Age-related left ventricular remodeling and associated risk for cardiovascular outcomes:the multi-ethnic study of atherosclerosis[J].Circ Cardiovasc Imaging, 2009, 2 (3):191-198.
[37]	Liu B, Dardeer AM, Moody WE, et al.Reference ranges for three-dimensional feature tracking cardiac magnetic resonance:comparison with two-dimensional methodology and relevance of age and gender[J].Int JCardiovasc Imaging, 2017, 2 (1):1-15.