Effect of anti-Helicobacter pylori treatment on blood lipids,carotid morphology and hemodynamics in patients with carotid plaque
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摘要: 目的：观察抗幽门螺杆菌（Hp）治疗对颈动脉斑块患者血脂和颈动脉形态和血流动力学的影响。方法：选取2017-12-2018-06于我院就诊的颈动脉斑块患者268例，根据数字随机法，将Hp感染合并颈动脉斑块患者分为A组和B组，每组134例；2组均给予常规降脂药和阿司匹林药物治疗，B组在A组基础上加用抗Hp治疗，于治疗前、后分别检测2组患者的血脂、颈动脉形态及血流动力学指标的变化情况。结果：2组患者的年龄、性别、心率、体质指数（BMI）、血压、血糖及肝肾功能均无明显差异（P>0.05），治疗前IMT、动脉内径、血流动力学和血脂水平亦无明显差异（P>0.05），治疗后IMT和动脉内径明显减少，而血流动力学指标和血脂水平得到明显改善（P<0.05），但B组降低和改善的程度更明显（P<0.05）。结论：高血压患者抗Hp治疗可更好地改善患者血脂、颈动脉形态和血流动力学参数异常。Abstract: Objective: To observe the effect of anti-Helicobacter pylori (Hp) on blood lipid, carotid morphology and hemodynamics in patients with carotid plaque.Method: A total of 268 patients with carotid plaque who were treated in our hospital from June 2017 to May 2018.According to the digital randomization method, patients with Hp infection and carotid plaque were divided into A and B groups.134 cases of each group, both groups A and B were given conventional lipid-lowering drugs and aspirin drugs, and group B was treated with anti-Hp in base of group A.Blood lipids, carotid morphology and hemodynamic parameters were measured before and after treatment.Result: There were no significant differences in age, heart rate, BMI, blood pressure, fasting glucose liver and renal function between the two groups (P>0.05).There was no significant difference in IMT, arterial diameter, hemodynamics and blood lipid levels between the two groups (P>0.05).After treatment, both IMT and arterial diameter were significantly reduced, hemodynamic parameters and blood lipid levels were significantly improved (P<0.05), but the reduction and improvement of group B were more significant (P<0.05).Conclusion: Anti-Hp treatment in patients with hypertension can improve the abnormalities of blood lipids, carotid morphology and hemodynamic parameters.
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Key words:
- helicobacter pylori /
- carotid plaque /
- blood lipids /
- carotid morphology /
- hemodynamics
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