血清胱抑素C水平与女性无慢性肾脏疾病患者冠状动脉钙化的相关性探讨

符武岛; 李伟; 曾敏; 郑茵; 陈娟; 冯光球; 管频

doi:10.13201/j.issn.1001-1439.2019.05.009

血清胱抑素C水平与女性无慢性肾脏疾病患者冠状动脉钙化的相关性探讨

- 海南省人民医院医疗保健中心(海口, 570311)

详细信息

通讯作者: 符武岛,E-mail:18389888186@163.com

中图分类号: R541.4

收稿日期: 2018-10-02

修回日期: 2018-10-20

Correlation between serum cystatin C level and coronary artery calcification in women without chronic kidney disease

- Hainan Provincial People's Hospital Medical and Health Center, Haikou, 570311, China

More Information

Corresponding author: FU Wudao, E-mail: 18389888186@163.com

Received Date: 02 October 2018

Revised Date: 20 October 2018

摘要

摘要: 目的：探讨血清胱抑素C及性别差异与无慢性肾脏病（CKD）患者冠状动脉钙化（CAC）的相关性。方法：评估456例无CKD和冠状动脉疾病的患者，平均年龄（61±13）岁，其中女性191例（42%）。CAC的严重程度采用AgtSton评分，并通过256排CT扫描获取。根据Agatston评分将CAC患者分为3组：轻度（0~9分）、中度（10~399分）和重度（≥400分）。结果：血清胱抑素C水平随着女性CAC严重程度的增加而逐渐增加，在男性患者中不明显。受试者工作特征曲线分析显示：在女性患者中，区分严重CAC的胱抑素C截点值为0.97 mg/L，敏感性为71%，特异性为77%（曲线下面积为0.74；95%CI：0.62~0.86，P<0.01）。多因素Logistic分析显示：男性患者的血清胱抑素C水平与严重CAC无关，但在女性患者中有明显的相关性（OR=7.80，胱抑素C≥0.97 mg/L，95%CI：1.76~34.60，P<0.01）。结论：无CKD的女性患者中较高的血清胱抑素C水平与较严重的CAC相关，血清胱抑素C有助于识别高心血管疾病风险的女性。
- 胱抑素C /
- 女性 /
- 冠状动脉钙化 /
- 相关性
Abstract: Objective: To investigate the relationship between serum cystatin C and gender differences in coronary artery calcification(CAC) in patients without chronic kidney disease (CKD).Method: A total of 456 patients coronary artery disease without CKD (age, 61±13 years, female 191 (42%)) were admitted.Coronary calcification severity was measured by a 256-slice CT scan and evaluated by the AgtSton score.Each gender was divided into three groups according to the Agatston score, mild(0 to 9 points), moderate(10 to 399 points) and severe (≥ 400 points).Result: Serum cystatin C levels gradually increased with the severity of female CAC but showed no significant trend in male.The receiver operating characteristic curve analysis showed that in women, the cut-off value of cystatin C in patients with severe CAC was 0.97 mg/L, the sensitivity was 71%, and the specificity was 77%(the area under the curve was 0.74, 95%CI:0.62-0.86, P<0.01).Multivariate logistic analysis showed that serum and cystatin C levels were not associated with severe CAC in all and male patients, but were significantly associated in female patients(OR=7.80, Cystatin C ≥ 0.97 mg/L, 95%CI:1.76-34.60, P<0.01).Conclusion: Higher serum cystatin C levels are associated with greater coronary calcification in women without CKD which may help identify women at high risk for cardiovascular disease.
- Cystatin C /
- female /
- coronary artery calcification /
- correlation

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