Abstract: Objective:To investigate the clinical characteristics and prognosis of elderly patients with acute ST-segment elevation myocardial infarction(STEMI) who underwent interventional therapy.Method:The clinical data of 139 consecutive elderly patients(≥75 years old)with acute STEMI who underwent primary percutaneous coronary intervention(PPCI) in our hospital from July 2015 to December 2017 were retrospectively collected.The patient's basic clinical data,coronary angiography,clinical medication and postoperative prognosis were analyzed.And factors influencing the adverse prognosis of PPCI therapy were analyzed by univariate and multivariate analysis.Result:Most of elderly patients with acute STEMI received PCI had hypertension(66.9%,n=93) and dyslipidemia 93.5%(n=130).Analysis of clinical medication data showed that fewer patients were treated with diuretics,accounting for only 30.2%(n=42).Patients with acute anterior inferior wall myocardial infarction and acute anterior wall myocardial infarction accounted for 92.1%(n=128).One-year follow-up showed that patients with good prognosis of interventional therapy accounted for 61.2%(n=65).The incidence of prognostic adverse events was higher in patients >85 years of age,left ventricular ejection fraction(LVEF)≤50%,and heart rate >75 times/min,respectively(P<0.05).Multivariate analysis showed that advanced age(OR=2.503,95%CI:1.014-6.179,P=0.047) and higher heart rate(OR=2.928,95%CI:1.379-6.216,P=0.005) were independent risk factors for poor prognosis in elderly patients with STEMI after PCI,and LVEF was a protective factor for poor prognosis in elderly patients with STEMI after PCI(OR=0.365,95%CI:0.174-0.769,P=0.008).Conclusion:Advanced age,lower LVEF,and higher heart rate are risk factors for poor prognosis in elderly patients with acute STEMI after PCI.