药物洗脱球囊治疗老年冠状动脉小血管病变的疗效及安全性分析

王一然; 阿荣; 王悦喜; 任家孚

doi:10.13201/j.issn.1001-1439.2019.12.012

药物洗脱球囊治疗老年冠状动脉小血管病变的疗效及安全性分析

- 内蒙古医科大学附属医院心内科(呼和浩特, 010050)
基金项目:
内蒙古自治区科学自然基金(No:2018MS08073)

内蒙古自治区高等教育厅科研计划项目(No:NJZY18109)

详细信息

通讯作者: 阿荣,E-mail:arong0308@126.com

中图分类号: R541.4

收稿日期: 2019-08-14

The effectiveness and safety of drug eluting balloon in elderly patients with small coronary vessel disease

- Department of Cardiology, Affiliated Hospital of Inner Mongolia medical university, Hohhot, Inner Mongolia, 010050, China

More Information

Corresponding author: A Rong, E-mail: arong0308@126.com

Received Date: 14 August 2019

摘要

摘要: 目的:观察药物洗脱球囊在老年冠状动脉(冠脉)小血管病变中应用的有效性和安全性,为老年冠心病患者的介入治疗提供更合理的治疗策略。方法:入选80例≥60岁需择期行介入治疗的冠脉小血管病变患者,随机分为药物洗脱球囊组(DEB组,30例)、药物洗脱支架组(DES组,25例)、普通球囊组(25例)。观察3组术后治疗效果、晚期管腔丢失(LLL)及主要心脏不良事件(MACE)。结果:①DEB和DES组术后即刻最小管腔直径无显著性差异;DES组最小管腔直径狭窄程度小于DEB组,但两组均明显优于普通球囊组(P<0.05)。②1年后随访造影,在最小管腔直径及最小管腔狭窄程度比较中,DEB和DES两组结果相似,均优于普通球囊组;对于LLL,DEB组显著优于DES和普通球囊组。③术后6个月,3组MACE比较差异无统计学意义;术后12个月,3组间MACE差异显著,其中DEB与DES组MACE发生率相似且更低(P<0.05)。结论:DEB治疗老年冠脉小血管病变不劣于DES,其具有良好疗效和安全性,且LLL优于DES。
- 药物洗脱球囊 /
- 老年 /
- 冠状动脉 /
- 小血管
Abstract: Objective:To observe the effectiveness and safety of drug eluting balloon for elderly patients with small coronary vessel disease,and to explore more reasonable strategy for interventional therapy.Method:A total of 80 cases aged 60 years and over admitted for coronary artery disease with small vessel and needed selective interventional therapy were selected.All patients were divided into drug eluting balloon group(DEB group,n=30),drug eluting stent group(DES group,n=25),and general balloon group(n=20).Treatment effect,late lumen loss and major adverse cardiac events were observed.Result:①There was no significant difference in the minimum lumen diameter after PCI immediately in DEB group and DES group,but they were superior to the normal balloon Group.While the minimum lumen stenosis rate of DES group was significantly lower than that of DEB group(P<0.05).②The results followed-up by angiography after 12 months of PCI showed that there was no significant difference in the minimum lumen diameter and restenosis rate between DEB and DES group,but both were superior to normal balloon group.The late lumen loss of DEB group was significantly lower than that of DES group(P<0.05).③Six months after PCI,there was no significant difference of MACE in the three groups.Twelve months after PCI,the incidence of MACE in DEB and DES group were comparable and significantly lower than that in normal balloon group(P<0.05).Conclusion:The efficacy and safety of DEB in elderly patients with small coronary vessel disease is as good as DES,and its late lumen loss is superior to DES.
- drug eluting balloon /
- elderly /
- coronary artery /
- small vessel disease

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