入院时血小板计数与淋巴细胞比值与AMI患者住院期间主要不良心血管事件的相关性

赵跃华; 王占启; 庞艳彬; 张蒙蒙

doi:10.13201/j.issn.1001-1439.2020.01.010

入院时血小板计数与淋巴细胞比值与AMI患者住院期间主要不良心血管事件的相关性

- 1. 河北大学附属医院心内科(河北保定, 071000);
- 2. 河北大学附属医院血液科;
- 3. 河北北方学院第一附属医院妇产科
基金项目:
保定市科技计划项目(No:17ZF194)

河北省老年病防治经费资助项目(No:361007)

详细信息

通讯作者: 王占启,E-mail:13930851971@163.com

中图分类号: R542.2

收稿日期: 2019-09-18

Correlation between platelet count and lymphocyte ratio at admission and major adverse cardiovascular events during hospitalization in patients with acute myocardial infarction

- 1. Department of Cardiology;
- 2. Department of Hematology, Affiliated Hospital of Hebei University, Hebei, 071000, China;
- 3. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Hebei North University

More Information

Corresponding author: WANG Zhanqi, E-mail: 13930851971@163.com

Received Date: 18 September 2019

摘要

摘要: 目的:研究评估入院时血小板与淋巴细胞比值(PLR)与急性心肌梗死(AMI)患者住院期间主要不良心血管事件(MACE)发生的相关性。方法:回顾性收集并分析自2017-10-2019-01于河北大学附属医院心血管重症监护室治疗的183例AMI患者,均于急诊科采血检测血常规,观察血小板和淋巴细胞绝对值,计算PLR,采用四分位数间距将PLR分为4组,1组:PLR<98.39(45例),2组:PLR 98.39~137.10(46例),3组:PLR 137.11~197.72(46例),4组:PLR>197.72(46例)。应用单因素和多因素Logistic回归分析PLR与住院期间MACE事件发生的相关性。应用Gensini积分评估冠状动脉病变严重程度。结果:不同PLR组间,冠状动脉Gensini积分、白细胞计数、淋巴细胞计数、中性粒细胞计数、中性粒与淋巴细胞比值、血小板计数差异有统计学意义,MACE事件的发生无显著差异。多变量Logistic回归分析表明Killip分级是影响AMI患者住院期间发生MACE的主要因素[OR(95%CI)=1.800(1.018~3.184),P=0.043]。同时PLR的多元多变量Logistic回归分析表明,NLR与PLR之间存在相关性[OR(95%CI)=9.015(2.334~34.813),P=0.001]。结论:PLR与AMI患者住院期间MACE的发生无显著相关,与冠状动脉病变程度无显著相关。
- 血小板计数 /
- 淋巴细胞计数 /
- 血小板与淋巴细胞比值 /
- 急性心肌梗死 /
- 主要不良心血管事件
Abstract: Objective:To evaluate the correlation between platelet/lymphocyte ratio(PLR) and major adverse cardiovascular events(MACE) during hospitalization in patients with acute myocardial infarction(AMI).Method:From October 2017 to January 2019,183 patients with AMI treated in the Cardiovascular intensive Care Unit of Affiliated Hospital of Hebei University were collected and analyzed.The absolute values of platelets and lymphocytes were observed and the ratio of platelets to lymphocytes was calculated.PLR was divided into 4 groups by quartile spacing:group 1:PLR＜98.39(n=45),group 2:PLR98.39~137.10(n=46).Group 3:PLR137.11~197.72(n=46),group 4:PLR＞197.72(n=46).Univariate and multivariate Logistic regression was used to analyze the correlation between PLR and MACE events during hospitalization.Gensini score was used to evaluate the severity of coronary artery disease.Result:There was significant difference in coronary artery Gensini score,WBC,LY,NE,NLR and PLT among different PLR groups,but there was no significant difference in the occurrence of MACE events.Multivariate Logistic regression analysis showed that Killip grade was the main factor affecting MACE events in patients with AMI during hospitalization [OR(95%CI)=1.800(1.018-3.184),P=0.043].At the same time,the multivariate Logistic regression analysis of PLR showed that there was a correlation between NLR and PLR [OR(95%CI)=9.015(2.334-34.813),P=0.001].Conclusion:There was no significant correlation between PLR and MACE during hospitalization in patients with AMI.
- platelet count /
- lymphocyte count /
- platelet and lymphocyte ratio /
- acute myocardial infarction /
- major adverse cardiovascular event

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