Meta-analysis of colchicine for prevention of atrial fibrillation after cardiac surgery or radiofrequency ablation
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摘要: 目的:评估秋水仙碱在预防心脏手术及射频消融术后心房颤动(房颤)的应用价值。方法:通过计算机检索Pubmed数据库、EMBASE数据库、Cochrane图书馆、中国生物医学文献数据库、CNKI数据库、万方中文科技期刊数据库(自建库起至2019年8月),搜集有关秋水仙碱应用于心脏手术及射频消融术的相关文章,评估秋水仙碱在降低术后房颤的临床应用价值。结果:纳入7篇随机对照研究,包含手术患者1779例,其中秋水仙碱组891例,对照组888例。在心脏外科手术患者中,秋水仙碱组发生房颤的风险明显低于对照组,差异有统计学意义(RR:0.68,95%CI:0.56~0.82,P<0.05),并且秋水仙碱组住院天数低于对照组,差异有统计学意义(MD=1.32,P<0.05);在房颤射频消融术中,使用秋水仙碱术后再发房颤的风险也明显低于对照组(RR:0.57,95%CI:0.43~0.78,P<0.05)。但是秋水仙碱组发生不良反应的风险明显高于对照组(RR=2.64,P<0.05)。结论:秋水仙碱能够有效地降低心脏外科手术及射频消融术后房颤的风险,具有广阔的应用前景。Abstract: Objective:To evaluate the value of colchicine for prevention of atrial fibrillation after cardiac surgery or radiofrequency ablation.Method:The related data were obtained from Pubmed,EMBASE,Cochrane library,China Biomedical Literature Database,CNKI,Wanfang Chinese Science and Technology Journal Database(from the establishment of the library until August 2019),and collected the articles about colchicine for cardiac surgery or radiofrequency ablation,and evaluated the clinical value of colchicine in reducing postoperative atrial fibrillation.Result:Seven randomized controlled studies included the 1779 patients with surgery or radiofrequency ablation,of them 891 patients in the colchicine group and 888 patients in the control group.Meta-analysis showed that in patients undergoing cardiac surgery,the risk of atrial fibrillation was significantly lower in the colchicine group than in the control group(RR:0.68,95%CI:0.56-0.82,P＜0.05),and the hospital length of stay in the colchicine group was lower than that in the control group(MD=1.32,P＜0.05).Among patients with atrial fibrillation undergoing radiofrequency ablation,the risk of recurrent atrial fibrillation was significantly lower in the colchicine group than in the control group(RR:0.57,95%CI:0.43 to 0.78,P＜0.05).However,the risk of adverse reactions was significantly higher in the colchicine group than in the control group(RR=2.64,P＜0.05).Conclusion:Colchicine can effectively reduce the risk of atrial fibrillation after cardiac surgery or radiofrequency ablation.
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Key words:
- colchicine /
- cardiac surgery /
- radiofrequency ablation /
- atrial fibrillation /
- meta-analysis
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