TRPV4在纤维化中的作用机制

杨翠; 陈闽伟; 黄峥嵘; 杜以梅

doi:10.13201/j.issn.1001-1439.2020.03.005

TRPV4在纤维化中的作用机制

- 1 厦门大学医学院(福建厦门, 361005);
- 2 厦门大学附属第一医院心内科;
- 3 华中科技大学同济医学院附属协和医院心内科离子通道实验室
基金项目:
国家自然科学基金(No:81770328)

详细信息

通讯作者: 杜以梅,E-mail:yimeidu@mail.hust.edu.cn

中图分类号: R965

收稿日期: 2019-07-09

The mechanism of TRPV4 in fibrosis

- 1 School of Medicine, Xiamen University, Xiamen, Fujian, 361005, China;
- 2 Department of Cardiology, The First Affiliated Hospital of Xiamen University;
- 3 Department of Cardiology, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology

More Information

Corresponding author: DU Yimei, E-mail: yimeidu@mail.hust.edu.cn

Received Date: 09 July 2019

摘要

摘要: 瞬时感受器电位离子通道香草素受体4(TRPV4)属于瞬时感受器电位离子通道家族中的一员,是一种非选择性阳离子通道,对钙离子具有适中通透性,其广泛分布在多种组织及器官中。近几年来,越来越多的研究表明,TRPV4与心脏、肺、胰腺、肾、肝、皮肤等多种组织及器官的纤维化发展进程关系密切,提示TRPV4可能成为抗纤维化治疗的潜在新靶点。本研究主要对TRPV4与纤维化关系的有关文献进行分析,归纳总结TRPV4与纤维化之间确切的信号通路及可能的潜在机制。同时也进一步讨论TRPV4作为抗纤维化治疗新靶点的潜力。
- TRPV4 /
- 纤维化 /
- 作用机制
Abstract: The transient receptor potential vanilloid 4(TRPV4),a member of the family of the transient receptor potential channels,is a non-selective cationic channel with moderate permeability to Ca²⁺.It is widely distributed in a variety of tissues and organs.In recent years,accumulating studies have shown that TRPV4 is closely related to the development fibrotic process of various tissues and organs,such as heart,lung,pancreas,kidney,liver,and skin,suggesting that TRPV4 may be a potential new target for anti-fibrosis therapy.In this review,we analyze the literature on the relationship between TRPV4 and fibrosis and summarize the specific signal pathways and possible mechanisms.In addition,the potential of TRPV4 as a new target for anti-fibrosis therapy is further discussed.
- TRPV4 /
- fibrosis /
- mechanism

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