Enhancing oxidative metabolism of branched chain amino acids can improve cardiac function in patients with heart failure
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摘要: 心力衰竭(HF)是指由于心脏的收缩功能和(或)舒张功能发生障碍,不能将静脉回心血量充分排出心脏,导致静脉系统血液淤积,动脉系统血液灌注不足,从而引起心脏循环障碍的临床综合征,此种心脏综合征会引起循环肺淤血、体循环淤血和组织血液灌注不足。HF的病理生理机制一直是研究的重点,旨在寻找更有效的预防和治疗手段。支链氨基酸是重要的必需氨基酸,其与心血管疾病的相关性研究越来越多。本文主要针对支链氨基酸代谢与HF的研究进展作一综述。Abstract: Heart failure is abbreviated as HF,which refers to the cardiac circulation disorder syndrome caused by insufficient blood perfusion in the arterial system and congestion of the venous system due to the obstruction of the systolic and/or diastolic functions of the heart.The main manifestations were pulmonary congestion,systemic congestion and insufficient tissue blood perfusion.The pathophysiological mechanism of heart failure has always been the focus of research,in order to find more effective means of prevention and treatment.Branched chain amino acids(BCAAs) are important essential amino acids,and their relationship with cardiovascular diseases has been studied more and more.This article reviews the research progress of branched chain amino acid metabolism and heart failure.
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