血清3-NT与急性ST段抬高型心肌梗死的相关性及其对行急诊经皮冠状动脉介入术后1年预后的预测价值

侯清濒; 靳春荣; 白雪琦; 吴琼; 范春雨; 贾永平

doi:10.13201/j.issn.1001-1439.2020.03.009

血清3-NT与急性ST段抬高型心肌梗死的相关性及其对行急诊经皮冠状动脉介入术后1年预后的预测价值

- 1 山西医科大学第一临床医学院(太原, 030001);
- 2 山西医科大学第一医院心内科
基金项目:
山西省卫生健康科研课题(No:2018035)

详细信息

通讯作者: 靳春荣,E-mail:jinchunrong525@sina.com

中图分类号: R542.22

收稿日期: 2019-10-23

修回日期: 2019-12-26

Correlation between serum 3-NT and severity of acute ST segment elevation myocardial infarction and its prognostic value in one year after emergency percutaneous coronary intervention

- 1 Department of First Clinical Medicine, Shanxi Medical University, Taiyuan, 030001, China;
- 2 Department of Cardiology, the First Hospital of Shanxi Medical University

More Information

Corresponding author: JIN Chunrong, E-mail: jinchunrong525@sina.com

Received Date: 23 October 2019

Revised Date: 26 December 2019

摘要

摘要: 目的:探讨血清3-硝基氨基酸(3-NT)与急性ST段抬高型心肌梗死(STEMI)的相关性及其对行急诊经皮冠状动脉介入术(PCI)后1年发生心血管不良事件(MACE)的预测价值。方法:选取2016年7月-2018年7月在我院行急诊PCI的STEMI患者共310例,根据PCI前SYNTAX评分将其分成低危组87例、中危组190例、高危组33例,酶联免疫法检测入院血清3-NT浓度,且用Spearman相关性分析研究血3-NT浓度与SYNTAX评分的相关性,随访患者1年,记录发生MACE情况,用Cox回归分析及绘制受试者工作特征(ROC)曲线评价STEMI患者入院血3-NT浓度对PCI术后1年预后的预测价值。结果:高危组入院血3-NT浓度高于低、中危组[(23.99±4.61)μg/ml∶(22.83±4.60)μg/ml∶(21.29±4.27)μg/ml,P＜0.05]。Spearman相关性分析示入院血3-NT浓度与SYNTAX评分呈正相关(r_s=0.516,P＜0.01)。Cox回归结果显示入院血3-NT浓度(HR=1.061,95%CI:1.002~1.124,P=0.042)是术后1年内发生MACE的独立危险因素。ROC结果示入院血3-NT浓度预测STEMI患者入院1年内发生MACE的ROC曲线下面积为0.68。结论:血清3-NT与STEMI病变严重程度呈显著正相关,是行急诊PCI后1年内出现MACE的独立危险因素。
- 3-硝基氨基酸 /
- 急性ST段抬高型心肌梗死 /
- 预后
Abstract: Objective:To investigate the correlation between serum 3-nitroamino acid(3-NT) and the severity of patients with acute ST segment elevation myocardial infarction(STEMI) and its predictive value for major adverse cardiovascular events(MACE) one year after emergency percutaneous coronary intervention(PCI).Method:STEMI patients(n=310) who were undergoing emergency PCI in the first Hospital of Shanxi Medical University from July 2016 to July 2018 were selected.According to the SYNTAX score before PCI,they were divided into low risk group(n=87),medium risk group(n=190),and high risk group(n=33).The plasma level of 3-NT were detected by ELISA at admission.Spearman correlation analysis was performed to detect the correlation between blood 3-NT concentration and SYNTAX score.All patients were followed up for 1 year to record the occurrence of MACE.The predictive value of the plasma level of 3-NT in patients with STEMI to the prognosis of 1 year after PCI was evaluated by COX regression analysis and ROC curve assessment.Result:Plasma level of 3-NT in high risk group was significantly higher than that in the low and medium risk group [(23.99±4.61) μg/ml∶(22.83±4.60) μg/ml∶(21.29±4.27) μg/ml,P＜0.05].The results of Spearman correlation analysis showed that the plasma level of 3-NT on admission was positively correlated with SYNTAX score(rs=0.547,P＜0.01).Cox regression showed that 3-NT concentration at admission(HR=1.061,95%CI:1.002-1.124,P=0.042) were independent risk factors for MACE within one year after PCI.The results of ROC showed that the AUC of 3-NT at admission for predicting MACE within one year after PCI in STEMI patients was 0.68.Conclusion:There is a significant positive correlation between serum 3-NT and the severity of STEMI.Serum 3-NTis an independent risk factor for MACE within 1 year after emergency PCI.
- 3-NT /
- acute ST segment elevation myocardial infarction /
- prognosis

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