Association between serum Klotho and metabolic disorders of glucose/lipids in patients with coronary atherosclerosis
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摘要: 目的:探讨冠状动脉粥样硬化患者血清Klotho水平与糖脂代谢紊乱的相关性。方法:采用横断面研究的方法,连续纳入2017年12月-2018年4月于我院心内科经冠状动脉造影确诊的308例冠状动脉粥样硬化患者,收集患者病史信息、实验室指标及冠状动脉造影数据,采用酶联免疫吸附试验检测血清Klotho水平。按血清Klotho中位数将研究人群分为低值组(≤296.8 pg/ml)和高值组(＞296.8 pg/ml),并比较两组间的临床资料。采用Spearman秩相关、ROC曲线、Logistic回归模型评估Klotho水平与糖脂代谢紊乱的相关性。结果:Klotho低值组脂质异常、糖代谢紊乱(GMD)和代谢综合征(MetS)的发生率显著高于高值组(P＜0.001);Klotho水平与糖脂代谢指标显著负相关(P＜0.05);脂质异常、GMD和MetS患者的Klotho水平较对照组显著降低(P＜0.001)。ROC曲线显示,Klotho对脂质异常、GMD和MetS具有较好的诊断效能,其曲线下面积分别为0.731、0.728和0.713(P＜0.001)。多因素Logistic回归分析进一步表明,Klotho与MetS独立显著相关(OR=0.991,95%CI:0.988~0.994,P＜0.001),高水平Klotho可能是MetS的保护性因素(OR=0.181,95%CI:0.101~0.327,P＜0.001)。结论:血清Klotho与糖脂代谢紊乱相关,低水平Klotho可能是MetS的独立危险因素。Abstract: Objective:To investigate the association of serum Klotho with metabolic disorders of glucose/lipids in patients with coronary atherosclerosis.Method:This was a cross-sectional study involving 308 patients diagnosed with coronary atherosclerosis by coronary angiography who were admitted between December 2017 and April 2018 in our hospital.The data about medical history,laboratory parameters,and coronary angiography were obtained from medical records.Serum Klotho was detected by Enzyme linked immunosorbent assay.According to Klotho median,the subjects were divided into the low Klotho group(≤296.8 pg/ml) and the high Klotho group(＞296.8 pg/ml),and clinical data between the two groups were compared.Spearman rank correlation analysis,ROC curve analysis,and Logistic regression models were performed to evaluate the association of Klotho with metabolic disorders of glucose and lipids.Result:The low Klotho group had higher incidences of dyslipidemia,glucose metabolism disorders(GMD),and metabolic syndrome(MetS)(P＜0.001).Serum Klotho was significantly negatively correlated with metabolic indicators(P＜0.05) Serum Klotho levels in patients with dyslipidemia,GMD,or MetS were significantly lower than those in the control group(P＜0.001).ROC curve analyses showed that Klotho had good diagnostic performances for dyslipidemia,GMDs and MetS;the area under the curve was 0.731,0.728 and 0.713,respectively(P＜0.001).Multivariate Logistic regression analysis further indicated that Klotho was significantly associated with MetS independently(OR=0.991,95%CI:0.988—0.994,P＜0.001);high Klotho might be a protective factor for MetS(OR=0.181,95%CI:0.101—0.327,P＜0.001).Conclusion:Serum Klotho is associated with metabolic disorders of glucose and lipids;and low Klotho may be an independent risk factor for MetS.
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Key words:
- Klotho /
- atherosclerosis /
- dyslipidemia /
- metabolic syndrome
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