ALP与冠状动脉斑块稳定性的相关性分析

任永奎; 王帅; 吕海辰; 李新生; 尹达; 刘鹏

doi:10.13201/j.issn.1001-1439.2020.03.011

ALP与冠状动脉斑块稳定性的相关性分析

- 1 大连医科大学附属第一医院心血管内科(辽宁大连, 116011)
基金项目:
大连市医学科学研究计划项目(No:1912019)

详细信息

通讯作者: 刘鹏,E-mail:liupeng840720@126.com

中图分类号: R541.4

收稿日期: 2019-05-05

修回日期: 2020-01-01

Correlation analysis between ALP and coronary plaque stability

- Department of Cardiovascular Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, China

More Information

Corresponding author: LIU Peng, E-mail: liupeng840720@126.com

Received Date: 05 May 2019

Revised Date: 01 January 2020

摘要

摘要: 目的:探讨急性冠状动脉综合征(ACS)患者中血清碱性磷酸酶(ALP)水平与血管内超声(IVUS)检测的斑块形态及钙化的相关性。方法:回顾性分析2017年1月-2018年12月行IVUS检查的ACS患者的影像学资料,排除既往PCI病史、癌症和肝脏疾病患者后,234例患者纳入本研究。采用受试者工作特征曲线(ROC)评估ALP预测钙化能力,并进行相关性分析。通过三分位法将患者分为高ALP(＞80 IU/L)组、中ALP(68~80 IU/L)组和低ALP(＜68 IU/L)组,观察不同水平ALP与钙化特征和斑块形态之间的相关性。结果:ROC曲线显示ALP预测钙化的AUC面积是0.65(P＜0.001);相关性分析提示ALP与斑块负荷(PB)相关(r_s=0.38,P＜0.001);高ALP组点状钙化、最小管腔面积(MLA)≤4.0 mm²及PB＞70%较中、低ALP组明显增高(P＜0.05),但薄层纤维帽(TCFA)和钙化长度在不同ALP组间比较差异无统计学意义(P＞0.05)。结论:ALP＞80 IU/L与点状钙化、PB、MLA的相关性较强,提示高ALP可能与斑块稳定性相关。
- 血管内超声 /
- 碱性磷酸酶 /
- 血管钙化
Abstract: Objective:To investigate the correlation between serum alkaline phosphatase(ALP) level and plaque morphology and calcification detected by intravascular ultrasound(IVUS) in acute coronary syndrome(ACS) patients.Method:The imaging data of ACS patients who underwent intravascular ultrasound(IVUS) examination from January 2017 to December 2018 were retrospectively analyzed.Patients with History of PCI,cancer,and liver disease were excluded,and 234 patients were included in this study,The receiver operating characteristic(ROC) was used to evaluate the predictive calcification ability and correlation analysis of ALP.Then ALP was divided into high ALP(＞80 IU/L) group,medium ALP(68—80 IU/L) group and low ALP(＜68 IU/L) group by the tertiles method,and to observe the correlation between different levels of ALP and calcification characteristics and plaque morphology.Result:The ROC curve showed that the AUC area of ALP predicted calcification was 0.65(P＜0.001).Correlation analysis indicated that there was a significant correlation between ALP and Plaque burden(PB)(r_s=0.38,P＜0.05).Spotty calcification,Minimum lumen area(MLA) 4.0 mm² and PB＞70% in the high ALP group were significantly higher than those in the middle ALP and low ALP group(P＜0.05).However,TCFA and calcification length were not statistically significant in different ALP groups(P＞0.05).Conclusion:The correlation between ALP＞80 IU/L and spotty calcification,PB and MLA is strong,suggesting that high ALP may be related to plaque stability.
- intravascular ultrasound /
- alkaline phosphatase /
- vascular calcification

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