中国人群载脂蛋白A5与动脉粥样硬化性心脑血管疾病

查艺闻; 梁景岩

doi:10.13201/j.issn.1001-1439.2020.10.018

中国人群载脂蛋白A5与动脉粥样硬化性心脑血管疾病

查艺闻¹,
梁景岩^2,3, ,

- 1. 扬州大学医学院(江苏扬州, 225001);
- 2. 扬州大学转化医学研究院;
- 3. 扬州大学江苏省中西医结合老年病防治重点实验室
基金项目:
国家重点研发计划(No:2016YFE0126000)

江苏省“六大人才高峰”高层次人才项目(No:2018WSN-082)

详细信息

通讯作者: 梁景岩,E-mail:jyliang@yzu.edu.cn

中图分类号: R541.4

收稿日期: 2020-04-25

修回日期: 2020-05-24

Apolipoprotein A5 in atherosclerotic cardio-cerebrovascular diseases in the Chinese population

ZHA Yiwen¹,
LIANG Jingyan^2,3, ,

- 1. Medical College, Yangzhou University, Yangzhou, Jiangsu, 225001, China;
- 2. Institute of Translational Medicine, Medical College, Yangzhou University;
- 3. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University

More Information

Corresponding author: LIANG Jingyan, E-mail: jyliang@yzu.edu.cn

Received Date: 25 April 2020

Revised Date: 24 May 2020

摘要

摘要: 载脂蛋白A5作为载脂蛋白家族的新成员,对血浆甘油三酯调节显著,其功能的缺失或障碍在动脉粥样硬化进程中发挥着不可忽视的作用,载脂蛋白A5基因的多态性在不同种族和地区对动脉粥样硬化性心脑血管疾病的影响存在差异。本文就载脂蛋白A5的结构、功能、机制以及近几年来有中国人群特异性的基因变异作一综述。
- 载脂蛋白 /
- 甘油三酯 /
- 动脉粥样硬化 /
- 心血管疾病 /
- 脑血管疾病
Abstract: Apolipoprotein A5, a novel member in the apolipoprotein family, plays an important role in regulating plasma triglycerides. Its dysfunction is associated with the progression of atherosclerosis. Its gene polymorphisms show different influence on the atherosclerotic cardio-cerebrovascular diseases within different regions and races. This review focuses on the structure, function, mechanism, and gene polymorphisms of apolipoprotein A5, particularly in the Chinese population in recent years.
- apolipoprotein /
- triglyceride /
- atherosclerosis /
- cardiovascular diseases /
- cerebrovascular disease

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