用于心脏修复与再生的可注射水凝胶的研究进展

樊景阳; 李苏雷; 曹丰

doi:10.13201/j.issn.1001-1439.2021.03.004

用于心脏修复与再生的可注射水凝胶的研究进展

- 1. 青岛大学医学部(山东青岛, 266071);
- 2. 解放军总医院第二医学中心;
- 3. 解放军总医院国家老年疾病临床医学研究中心
基金项目:
国家自然科学基金重点国际(地区)合作研究项目(No:81820108019)

详细信息

通讯作者: 曹丰,E-mail:fengcao8828@163.com

中图分类号: R542.2

收稿日期: 2020-09-05

修回日期: 2020-10-27

Research progress of injectable hydrogels for cardiac repair and regeneration

- 1. Department of Medicine, Qingdao University, Qingdao, Shandong, 266071, China;
- 2. Second Medical Center;
- 3. National Clinical Medical Research Center for Geriatric Diseases, PLA General Hospital

More Information

Corresponding author: CAO Feng, E-mail: fengcao8828@163.com

Received Date: 05 September 2020

Revised Date: 27 October 2020

摘要

摘要: 心肌梗死是威胁人类健康的重大疾病之一。心肌梗死后大量心肌细胞发生坏死并形成瘢痕,最终导致心力衰竭。目前,治疗终末期心力衰竭的方法包括药物治疗、左心室辅助装置植入和心脏移植,但这些方法都存在一定局限性。细胞移植进行心脏修复与再生是一种有前景的心力衰竭治疗方法,但移植后细胞的低滞留率和低存活率大大限制了其在临床的推广应用。可注射水凝胶可以作为移植细胞的载体,通过微创的方式进行心肌注射改善细胞的植入和存活,使其在心脏组织工程中更具吸引力。本文拟对多种可注射水凝胶的特点及最新研究进展进行综述。
- 组织工程 /
- 水凝胶 /
- 心肌梗死 /
- 心力衰竭 /
- 细胞移植
Abstract: Myocardial infarction is one of the major diseases threatening human health. Massive myocyte necrosis and scar formation following myocardial infarction eventually led to heart failure. At present, the methods of treating end-stage heart failure are including drug therapy, left ventricular assist devices implantation, and heart transplantation, but all of them have some limitations. The application of cell transplantation for heart repair and regeneration is a promising treatment for heart failure, but the low retention and survival of transplanted cells greatly limits its clinical application. Injectable hydrogels can be used as carriers for transplanted cells to improve cell implantation and survival. Moreover, hydrogels are able to perform myocardial injection therapy in a minimally invasive manner, making it more attractive in cardiac tissue engineering. This review gives a brief overview of injectable hydrogels, including the characteristics and recent research progress of various injectable hydrogels.
- tissue engineering /
- hydrogels /
- myocardial infarction /
- heart failure /
- cellular transplantation

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