2型糖尿病与血管衰老研究进展

马雅楠; 刘德敏; 谷国强

doi:10.13201/j.issn.1001-1439.2021.09.003

2型糖尿病与血管衰老研究进展

- 河北医科大学第二医院心内科(石家庄, 050000)
基金项目:
河北省自然科学基金精准医学联合基金重点项目(No:H2020206409)

心血管联盟默克基金(No:2017-CCA-xinxinmerckfund-011)

详细信息

通讯作者: 谷国强,E-mail:guguoqiang72@163.com

中图分类号: R587.1

收稿日期: 2021-01-27

Progress of type 2 diabetes mellitus on vascular aging

- Department of Cardiology, The Second Hospital of Hebei Medical University, Institute of Cardiocerebrovascular Disease of Hebei Province, Hebei, 050000, China

More Information

Corresponding author: GU Guoqiang, E-mail: guguoqiang72@163.com

Received Date: 27 January 2021

摘要

摘要: 衰老是人类疾病的主要危险因素,延缓衰老已成为提高生活质量的紧迫问题。其中血管衰老贯穿于年龄相关疾病(如2型糖尿病、神经退行性疾病、动脉粥样硬化、高血压)的整个发生、发展及演变过程。2型糖尿病作为血管病变的发病基础,在血管衰老过程中扮演何种角色,是目前学术界研究的热点。本文旨在对2型糖尿病在血管衰老相关疾病中的作用机制进行综述,以期深入认识2型糖尿病背景下血管衰老的特点,并为对其早期干预提供理论依据。
- 血管衰老 /
- 2型糖尿病 /
- 内皮细胞 /
- 平滑肌细胞
Abstract: Aging is a major risk factor for human diseases, and delaying or reducing aging has become an urgent issue for improving the quality of life. Among them, vascular aging runs through the whole process of occurrence, development and evolution of age-related diseases(such as diabetes mellitus, neurodegenerative diseases, atherosclerosis, and hypertension). As the basis of the pathogenesis of vascular disease, what role does diabetes play in the process of vascular aging is a hot spot in the academic field. This article aims to review the latest research results on the mechanism and treatment of type 2 diabetes in cardiovascular aging-related diseases.
- vascular aging /
- diabetes mellitus /
- endothelium cell /
- vascular smooth muscle cell

HTML全文

参考文献(53)

[1]	Ryder JR,Northrop E,Rudser KD,et al.Accelerated early vascular aging among adolescents with obesity and/or type 2 diabetes mellitus[J].J Am Heart Assoc,2020,9(10):e014891.
[2]	El-Seweidy MM,Sarhan Amin R,Husseini Atteia H,et al.Dyslipidemia induced inflammatory status,platelet activation and endothelial dysfunction in rabbits:Protective role of 10-Dehydrogingerdione[J].Biomed Pharmacother,2019,110:456-464.
[3]	Cunha PG,Boutouyrie P,Nilsson PM,et al.Early Vascular Ageing(EVA):definitions and clinical applicability[J].Curr Hypertens Rev,2017,13(1):8-15.
[4]	Lim K,Halim A,Lu TS,et al.Klotho:A major shareholder in vascular aging enterprises[J].Int J Mol Sci,2019,20(18):111.
[5]	Ni YQ,Lin X,Zhan JK,et al.Roles and functions of exosomal non-coding RNAs in vascular aging[J].Aging Dis,2020,11(1):164-178.
[6]	Pinti MV,Fink GK,Hathaway QA,et al.Mitochondrial dysfunction in type 2 diabetes mellitus:an organ-based analysis[J].Am J Physiol Endocrinol Metab,2019,316(2):E268-E285.
[7]	Jia G,Aroor AR,Jia C,et al.Endothelial cell senescence in aging-related vascular dysfunction[J].Biochim Biophys Acta Mol Basis Dis,2019,1865(7):1802-1809.
[8]	Hohensinner PJ,Kaun C,Buchberger E,et al.Age intrinsic loss of telomere protection via TRF1 reduction in endothelial cells[J].Biochim Biophys Acta,2016,1863(2):360-367.
[9]	Bubb KJ,Drummond GR,Figtree GA.New opportunities for targeting redox dysregulation in cardiovascular disease[J].Cardiovasc Res,2020,116(3):532-544.
[10]	Login CC,Baldea I,Tiperciuc B,et al.A novel thiazolyl schiff base:antibacterial and antifungal effects and in vitro oxidative stress modulation on human endothelial cells[J].Oxid Med Cell Longev,2019,2019:1607903.
[11]	Talepoor AG,Fouladseresht H,Khosropanah S,et al.Immune-inflammation in atherosclerosis:a new twist in an old tale[J].Endocr Metab Immune Disord Drug Targets,2020,20(4):525-545.
[12]	Ito F,Sono Y,Ito T.Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress:oxidative stress in diabetes,atherosclerosis,and chronic inflammation[J].Antioxidants(Basel),2019,8(3):111.
[13]	Pandolfi A,De Filippis EA.Chronic hyperglicemia and nitric oxide bioavailability play a pivotal role in pro-atherogenic vascular modifications[J].Genes Nutr,2007,2(2):195-208.
[14]	Liu TS,Pei YH,Peng YP,et al.Oscillating high glucose enhances oxidative stress and apoptosis in human coronary artery endothelial cells[J].J Endocrinol Invest,2014,37(7):645-651.
[15]	Alizadeh S,Mirshafiey A,Djalali M,et al.Vitamin D3 induces gene expression of ox-LDL scavenger receptors in streptozotocin-induced diabetic rat aortas:new insight into the role of Vitamin D in diabetic atherosclerosis[J].Rep Biochem Mol Biol,2018,6(2):170-177.
[16]	Cai Y,Xu L,Xu C,et al.Hsa_circ_0001445 inhibits ox-LDL-induced HUVECs inflammation,oxidative stress and apoptosis by regulating miRNA-640[J].Perfusion,2020:267659120979472.
[17]	Luo Y,Lu S,Dong X,et al.Dihydromyricetin protects human umbilical vein endothelial cells from injury through ERK and Akt mediated Nrf2/HO-1 signaling pathway[J].Apoptosis,2017,22(8):1013-1024.
[18]	Ito F,Ito T,Suzuki C,et al.The application of a modified d-ROMs test for measurement of oxidative stress and oxidized high-density lipoprotein[J].Int J Mol Sci,2017,18(2):111.
[19]	Donato AJ,Walker AE,Magerko KA,et al.Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice[J].Aging Cell,2013,12(5):772-783.
[20]	Poznyak A,Grechko AV,Poggio P,et al.The diabetes mellitus-atherosclerosis connection:the role of lipid and glucose metabolism and chronic inflammation[J].Int J Mol Sci,2020,21(5):111.
[21]	Hudson BI,Lippman ME.Targeting RAGE Signaling in Inflammatory Disease[J].Annu Rev Med,2018,69:349-364.
[22]	Bhardwaj R,Singh BP,Sandhu N,et al.Probiotic mediated NF-κB regulation for prospective management of type 2 diabetes[J].Mol Biol Rep,2020,47(3):2301-2313.
[23]	Enzerink A,Vaheri A.Fibroblast activation in vascular inflammation[J].J Thromb Haemost,2011,9(4):619-626.
[24]	Huang D,Gao W,Zhong X,et al.NLRP3 activation in endothelia promotes development of diabetes-associated atherosclerosis[J].Aging(Albany NY),2020,12(18):18181-18191.
[25]	Jin H,Zhu Y,Wang XD,et al.BDNF corrects NLRP3 inflammasome-induced pyroptosis and glucose metabolism reprogramming through KLF2/HK1 pathway in vascular endothelial cells[J].Cell Signal,2021,78:109843.
[26]	Yin Y,Zhou Z,Liu W,et al.Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3(NLRP3) inflammasome activation via reactive oxygen species(ROS)/thioredoxin-interacting protein(TXNIP)pathway[J].Int J Biochem Cell Biol,2017,84:22-34.
[27]	Hansen M,Rubinsztein DC,Walker DW.Publisher Correction:Autophagy as a promoter of longevity:insights from model organisms[J].Nat Rev Mol Cell Biol,2018,19(9):611.
[28]	Aragonès G,Dasuri K,Olukorede O,et al.Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability[J].Aging Cell,2020,19(11):e13257.
[29]	Zhang H,Ge S,He K,et al.FoxO1 inhibits autophagosome-lysosome fusion leading to endothelial autophagic-apoptosis in diabetes[J].Cardiovasc Res,2019,115(14):2008-2020.
[30]	Aki T,Unuma K,Noritake K,et al.Formation of high molecular weight p62 by CORM-3[J].PLoS One,2019,14(1):e0210474.
[31]	Zhang Y,Cross SD,Stanton JB,et al.Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7[J].Mol Vis,2017,23:228-241.
[32]	Phadwal K,Feng D,Zhu D,et al.Autophagy as a novel therapeutic target in vascular calcification[J].Pharmacol Ther,2020,206:107430.
[33]	Moldogazieva NT,Mokhosoev IM,Mel'nikova TI,et al.Oxidative Stress and Advanced Lipoxidation and Glycation End Products(ALEs and AGEs)in Aging and Age-Related Diseases[J].Oxid Med Cell Longev,2019,2019:3085756.
[34]	Chi C,Li DJ,Jiang YJ,et al.Vascular smooth muscle cell senescence and age-related diseases:State of the art[J].Biochim Biophys Acta Mol Basis Dis,2019,1865(7):1810-1821.
[35]	Lacolley P,Regnault V,Avolio AP.Smooth muscle cell and arterial aging:basic and clinical aspects[J].Cardiovasc Res,2018,114(4):513-528.
[36]	Durham AL,Speer MY,Scatena M,et al.Role of smooth muscle cells in vascular calcification:implications in atherosclerosis and arterial stiffness[J].Cardiovasc Res,2018,114(4):590-600.
[37]	李秀丹,石立力,姜晓艳.血管平滑肌细胞自噬与糖尿病动脉粥样硬化关系的研究进展[J].临床心血管病杂志,2019,35(1):92-95.
[38]	Poetsch F,Henze LA,Estepa M,et al.Role of SGK1 in the Osteogenic Transdifferentiation and Calcification of Vascular Smooth Muscle Cells Promoted by Hyperglycemic Conditions[J].Int J Mol Sci,2020,21(19):111.
[39]	Lin X,Zhan JK,Zhong JY,et al.lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs[J].Aging(Albany NY),2019,11(2):523-535.
[40]	Lacolley P,Regnault V,Laurent S.Mechanisms of arterial stiffening:from mechanotransduction to epigenetics[J].Arterioscler Thromb Vasc Biol,2020,40(5):1055-1062.
[41]	Castro JP,Jung T,Grune T,et al.4-Hydroxynonenal(HNE)modified proteins in metabolic diseases[J].Free Radic Biol Med,2017,111:309-315.
[42]	Reddy MA,Das S,Zhuo C,et al.Regulation of vascular smooth muscle cell dysfunction under diabetic conditions by miR-504[J].Arterioscler Thromb Vasc Biol,2016,36(5):864-873.
[43]	Park HS,Han JH,Jung SH,et al.Anti-apoptotic effects of autophagy via ROS regulation in microtubule-targeted and PDGF-stimulated vascular smooth muscle cells[J].Korean J Physiol Pharmacol,2018,22(3):349-360.
[44]	薛新月,畅智慧,刘兆玉.血管平滑肌细胞在血管钙化中的调控机制研究进展[J].临床心血管病杂志,2020,36(9):870-873.
[45]	Shyu KG,Cheng WP,Wang BW.Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions.Mol Med.2015.21(1):616-625.
[46]	Nanayakkara G,Viswaprakash N,Zhong J,et al.PPARγ activation improves the molecular and functional components of I(to)remodeling by angiotensin II[J].Curr Pharm Des,2013,19(27):4839-4847.
[47]	Wang X,Khalil RA.Matrix Metalloproteinases,Vascular Remodeling,and Vascular Disease[J].Adv Pharmacol,2018,81:241-330.
[48]	Harvey A,Montezano AC,Lopes RA,et al.Vascular Fibrosis in Aging and Hypertension:Molecular Mechanisms and Clinical Implications[J].Can J Cardiol,2016,32(5):659-668.
[49]	Du Y,Han J,Zhang H,et al.Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress[J].J Cardiovasc Pharmacol,2019,74(4):326-335.
[50]	Altenhöfer S,Kleikers PW,Radermacher KA,et al.The NOX toolbox:validating the role of NADPH oxidases in physiology and disease[J].Cell Mol Life Sci,2012,69(14):2327-2343.
[51]	Liu Y,Liang C,Liu X,et al.AGEs increased migration and inflammatory responses of adventitial fibroblasts via RAGE,MAPK and NF-kappaB pathways[J].Atherosclerosis,2010,208(1):34-42.
[52]	Burr SD,Stewart JA Jr.Extracellular matrix components isolated from diabetic mice alter cardiac fibroblast function through the AGE/RAGE signaling cascade[J].Life Sci,2020,250:117569.
[53]	Wang HF,Yu QQ,Zheng RF,et al.Inhibition of vascular adventitial remodeling by netrin-1 in diabetic rats[J].J Endocrinol,2020,244(3):445-458.