-
摘要: 心房衰竭是指心房功能障碍导致的心脏功能障碍。本文从心房解剖、生理到心房衰竭的病理生理、临床表现、评估与潜在治疗靶点,对心房衰竭作一综述。“心房衰竭”作为一个独立临床疾病概念的提出有助于推动深入研究与认识左心房功能障碍,进而寻找新的精准治疗靶点。Abstract: Atrial failure refers to any atrial dysfunction causing impaired heart performance. We reviewed atrial anatomy and physiology, aspects of pathophysiology, clinical consequences, evaluation methods, and potential interventions of atrial failure. The concept of "atrial failure" as a clinical entity may improve understanding and precise management of atrial dysfunction.
-
Key words:
- atrial failure /
- atrial fibrillation /
- heart failure /
- atrial dysfunction
-
-
[1] Simões-Costa MS,Vasconcelos M,Sampaio AC,et al.The evolutionary origin of cardiac chambers[J].Dev Biol,2005,277(1):1-15.
[2] Bisbal F,Baranchuk A,Braunwald E,et al.Atrial failure as a clinical entity:JACC Review Topic of the Week[J].J Am Coll Cardiol,2020,75(2):222-232.
[3] Kilner PJ,Yang GZ,Wilkes AJ,et al.Asymmetric redirection of flow through the heart[J].Nature,2000,404(6779):759-761.
[4] Sherif HM.The developing pulmonary veins and left atrium:implications for ablation strategy for atrial fibrillation[J].Eur J Cardiothorac Surg,2013,44(5):792-799.
[5] Ho SY,Sanchez-Quintana D,Cabrera JA,et al.Anatomy of the left atrium:implications for radiofrequency ablation of atrial fibrillation[J].J Cardiovasc Electrophysiol,1999,10(11):1525-1533.
[6] Seward JB,Hebl VB.Left atrial anatomy and physiology:echo/Doppler assessment[J].Curr Opin Cardiol,2014,29(5):403-407.
[7] van Campenhout MJ,Yaksh A,Kik C,et al.Bachmann's bundle:a key player in the development of atrial fibrillation?[J].Circ Arrhythm Electrophysiol,2013,6(5):1041-1046.
[8] Triposkiadis F,Pieske B,Butler J,et al.Global left atrial failure in heart failure[J].Eur J Heart Fail,2016,18(11):1307-1320.
[9] Bayés de Luna A,Platonov P,Cosio FG,et al.Interatrial blocks.A separate entity from left atrial enlargement:a consensus report[J].J Electrocardiol,2012,45(5):445-451.
[10] Burstein B,Libby E,Calderone A,et al.Differential behaviors of atrial versus ventricular fibroblasts:apotential role for platelet-derived growth factor in atrialventricular remodeling differences[J].Circulation,2008,117(13):1630-1641.
[11] 魏飞宇,范洁,高田,等.miR-199-3p通过靶向调控SP1促进成纤维细胞增殖对心房颤动心房重构的影响[J].临床心血管病杂志,2020,36(6):523-530.
[12] Ling LH,Kistler PM,Ellims AH,et al.Diffuse ventricular fibrosis in atrial fibrillation:noninvasive evaluation and relationships with aging and systolic dysfunction[J].J Am Coll Cardiol,2012,60(23):2402-2408.
[13] Goette A,Kalman JM,Aguinaga L,et al.EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies:definition,characterization,and clinical implication[J].Europace,2016,18(10):1455-1490.
[14] Aguero J,Galan-Arriola C,Fernandez-Jimenez R,et al.Atrial infarction and ischemic mitral regurgitation contribute to post-MI remodeling of the left atrium[J].J Am Coll Cardiol,2017,70(23):2878-2889.
[15] Miller JD,Aronis KN,Chrispin J,et al.Obesity,exercise,obstructive sleep apnea,and modifiable atherosclerotic cardiovascular disease risk factors in atrial fibrillation[J].J Am Coll Cardiol,2015,66(25):2899-2906.
[16] Sivalokanathan S,Zghaib T,Greenland GV,et al.Hypertrophic cardiomyopathy patients with paroxysmal atrial fibrillation have a high burden of left atrial fibrosis by cardiac magnetic resonance imaging[J].JACC Clin Electrophysiol,2019,5(3):364-375.
[17] 金雪娟,周京敏.心力衰竭与心房颤动共存的流行病学和相关临床研究进展[J].临床心血管病杂志,2019,35(3):199-202.
[18] King JB,Azadani PN,Suksaranjit P,et al.Left atrial fibrosis and risk of cerebrovascular and cardiovascular events in patients with atrial fibrillation[J].J Am Coll Cardiol,2017,70(11):1311-1321.
[19] Gaita F,Blandino A.Atrial fibrillation.Left atrial fibrosis--apromising stroke risk factor?[J].Nat Rev Cardiol,2011,8(6):307-308.
[20] 佘飘飘,王德国.心房心肌病心电图标志与隐源性卒中相关性的研究进展[J].实用心电学杂志,2020,29(5):363-366.
[21] Brambatti M,Connolly SJ,Gold MR,et al.Temporal relationship between subclinical atrial fibrillation and embolic events[J].Circulation,2014,129(21):2094-2049.
[22] Calenda BW,Fuster V,Halperin JL,et al.Stroke risk assessment in atrial fibrillation:risk factors and markers of atrial myopathy[J].Nat Rev Cardiol,2016,13(9):549-559.
[23] von Roeder M,Rommel KP,Kowallick JT,et al.Influence of left atrial function on exercise capacity and left ventricular function in patients with heart failure and preserved ejection fraction[J].Circ Cardiovasc Imaging,2017,10(4).
[24] 杨颖,张宝娓,齐丽彤,等.高血压患者左心房大小与时相功能的关系[J].中华超声影像学杂志,2013,22(12):1013-1016.
[25] 廖曼,尚小珂,张长东,等.心房分流术治疗心力衰竭的研究进展[J].临床心血管病杂志,2020,36(3):222-227.
[26] Eicher JC,Laurent G,MathéA et al.Atrial dyssynchrony syndrome:an overlooked phenomenon and a potential cause of'diastolic'heart failure[J].Eur JHeart Fail,2012,14(3):248-258.
[27] Sanchis L,Gabrielli L,Andrea R,et al.Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection fraction[J].Eur Heart J Cardiovasc Imaging,2015,16(1):62-67.
[28] 卢永昕.HFpEF精准医疗时代到来了吗?[J].临床心血管病杂志,2019,35(4):295-296.
[29] Sandoval Y,Smith SW,Thordsen SE,et al.Supply/demand type 2myocardial infarction:should we be paying more attention?[J].J Am Coll Cardiol,2014,63(20):2079-2087.
[30] Deferm S,Bertrand PB,Verbrugge FH,et al.Atrial functional mitral regurgitation:JACC review topic of the week[J].J Am Coll Cardiol,2019,73(19):2465-2476.
[31] 杨颖,张宝娓,齐丽彤,等.斑点追踪技术评价高血压患者左心房时相功能变化[J].北京大学学报(医学版),2014,46(4):596-600.
[32] Cameli M,Sparla S,Losito M,et al.Correlation of left atrial strain and doppler measurements with invasive measurement of left ventricular end-diastolic pressure in patients stratified for different values of ejection fraction[J].Echocardiography,2016,33(3):398-405.
[33] Markl M,Lee DC,Ng J,et al.Left atrial 4-dimensional flow magnetic resonance imaging:stasis and velocity mapping in patients with atrial fibrillation[J].Invest Radiol,2016,51(3):147-154.
[34] Schumacher K,Dagres N,Hindricks G,et al.Characteristics of PR interval as predictor for atrial fibrillation:association with biomarkers and outcomes[J].Clin Res Cardiol,2017,106(10):767-775.
[35] Aro AL,Anttonen O,Kerola T,et al.Prognostic significance of prolonged PR interval in the general population[J].Eur Heart J,2014,35(2):123-129.
[36] Dilaveris PE,Gialafos JE.P-wave dispersion:a novel predictor of paroxysmal atrial fibrillation[J].Ann Noninvasive Electrocardiol,2001,6(2):159-165.
[37] He J,Tse G,Korantzopoulos P,et al.P-wave indices and risk of ischemic stroke:a systematic review and meta-analysis[J].Stroke,2017,48(8):2066-2072.
-
计量
- 文章访问数: 326
- PDF下载数: 0
- 施引文献: 0
下载: