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摘要: 微颗粒(microparticles, MPs)是细胞在应激或损伤条件下,从质膜脱落到胞外的微小膜性囊泡。不同细胞来源的MPs,除对炎症、凝血、肿瘤等有影响外,在冠心病中的作用也受到广泛关注。有利的方面,在冠心病的发生发展过程中,具有保护心肌的作用,并且MPs循环浓度及表面标志可区分不同类型、不同程度的冠心病,故可作为区分疾病和判断损伤程度的标志。有弊的方面,MPs直接或间接参与内皮功能恶化、血栓形成和心肌损伤等一系列病理过程,与冠心病发生、发展的进程密切相关,有望作为干预和治疗的潜在靶点。Abstract: Microparticles(MPs) are small membranous vesicles that are shed from membrane to extracellular under stress or injury. In addition to the effects on inflammation, coagulation, tumor, and so on, the role of different cell-derived microparticles in coronary heart disease has also been widely concerned. On the positive side, it can protect the myocardium in the occurrence and development of coronary heart disease, and MPs circulating concentration and surface markers can distinguish different types and degrees of coronary heart disease, so it can be used as a marker to distinguish diseases and judge the degree of injury. On the down side, MPs directly or indirectly are involved in a series of pathological processes such as endothelial function deterioration, thrombosis, and myocardial injury. It is closely related to the occurrence and development of coronary heart disease and is expected to be a potential target for intervention and treatment.
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Key words:
- coronary heart disease /
- microparticles /
- endothelial cell /
- platelet
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[1] 俞旭华.气泡诱导的内皮微粒在减压病血管炎性损伤中的作用及其形成机制[D].中国人民解放军海军军医大学,2018.
[2] Morel O,Jesel L,Freyssinet JM,et al.Cellular mechanisms underlying the formation of circulating microparticles[J].Arterioscler Thromb Vasc Biol,2011,31(1):15-26.
[3] Said AS,Doctor A.Influence of red blood cell-derived microparticles upon vasoregulation[J].Blood Transfus,2017,15(6):522-534.
[4] 陈英华,冯波.糖基化终末产物诱导内皮微颗粒释放[J].安徽医科大学学报,2020,55(2):268-271,276.
[5] Caspers M,Schäfer N,Fröhlich M,et al.Microparticles profiling in trauma patients:high level of microparticles induce activation of platelets in vitro[J].Eur J Trauma Emerg Surg,2020,46(1):43-51.
[6] 袁玉娟,李吉斌,李昊,等.急性心肌梗死与冠状动脉血内皮细胞源微粒、组织因子和白细胞介素-33的相关性研究[J].临床心血管病杂志,2021,37(4):328-332.
[7] 刘少飞,匡雅姝,彭盛,等.单核细胞来源的微颗粒通过PPAR-α-SR-BI途径促进RAW264.7泡沫细胞形成的研究[J].同济大学学报(医学版),2017,38(4):6-12.
[8] Kim Y,Abplanalp WA,Jung AD,et al.Endocytosis of red blood cell microparticles by pulmonary endothelial cells is mediated by Rab5[J].Shock,2018,49(3):288-294.
[9] 黄波.肿瘤囊泡:通向肿瘤免疫生物治疗之路[J].中国肿瘤生物治疗杂志,2015,22(5):551-557.
[10] Straat M,Böing AN,Tuip-De Boer A,et al.Extracellular vesicles from red blood cell products induce a strong pro-inflammatory host response,dependent on both numbers and storage duration[J].Transfus Med Hemother,2016,43(4):302-305.
[11] Liu A,Zhang X,He H,et al.Therapeutic potential of mesenchymal stem/stromal cell-derived secretome and vesicles for lung injury and disease[J].Expert Opin Biol Ther,2020,20(2):125-140.
[12] Ueba T,Nomura S,Inami N,et al.Plasma level of platelet-derived microparticles is associated with coronary heart disease risk score in healthy men[J].J Atheroscler Thromb,2010,17(4):342-349.
[13] Hameed A,Rubab Z,Abbas Rizvi SK,et al.Levels of platelet-derived microparticles and soluble p-selectin in patients of acute myocardial infarction(case control study)[J].J Pak Med Assoc,2017,67(7):998-1003.
[14] Christersson C,Thulin Â,Siegbahn A.Microparticles during long-term follow-up after acute myocardial infarction.Association to atherosclerotic burden and risk of cardiovascular events[J].Thromb Haemost,2017,117(8):1571-1581.
[15] Hartopo AB,Puspitawati I,Gharini PP,et al.Platelet microparticle number is associated with the extent of myocardial damage in acute myocardial infarction[J].Arch Med Sci,2016,12(3):529-537.
[16] George M,Ganesh MR,Sridhar A,et al.Evaluation of endothelial and platelet derived microparticles in patients with acute coronary syndrome[J].J Clin Diagn Res,2015,9(12):OC09-13.
[17] Chiva-Blanch G,Laake K,Myhre P,et al.Platelet-,monocyte-derived and tissue factor-carrying circulating microparticles are related to acute myocardial infarction severity[J].PLoS One,2017,12(2):e0172558.
[18] Zhou B,Li J,Chen S,et al.Time course of various cell origin circulating microparticles in ST-segment elevation myocardial infarction patients undergoing percutaneous transluminal coronary intervention[J].Exp Ther Med,2016,11(4):1481-1486.
[19] Ma F,Liu H,Shen Y,et al.Platelet-derived microvesicles are involved in cardio-protective effects of remote preconditioning[J].Int J Clin Exp Pathol,2015,8(9):10832-10839.
[20] Liu M,Wang Y,Zhu Q,et al.Protective effects of circulating microvesicles derived from ischemic preconditioning on myocardial ischemia/reperfusion injury in rats by inhibiting endoplasmic reticulum stress[J].Apoptosis,2018,23(7-8):436-448.
[21] Yang Y,Luo H,Liu S,et al.Platelet microparticles-containing miR-4306 inhibits human monocyte-derived macrophages migration through VEGFA/ERK1/2/NF-κB signaling pathways[J].Clin Exp Hypertens,2019,41(5):481-491.
[22] Mathiyalagan P,Liang Y,Kim D,et al.Angiogenic mechanisms of human CD34+ stem cell exosomes in the repair of ischemic hindlimb[J].Circ Res,2017,120(9):1466-1476.
[23] Pan C,Gao H,Zheng N,et al.MiR-320 inhibits the growth of glioma cells through downregulating PBX3[J].Biol Res,2017,50(1):31.
[24] 李恩,汪涛,张丽华,等.急性冠脉综合征患者血清miRNA-208与血小板功能的关系[J].郑州大学学报(医学版),2017,52(2):188-190.
[25] Geng XY,Xiao N,Han Y,et al.Platelet microparticles:a tool to predict infarction area in rats[J].J Invest Surg,2021,34(1):64-69.
[26] 阿地里江·肉孜,袁玉娟,穆叶赛·尼加提.冠状动脉血和静脉血内皮细胞微粒研究[J].临床心血管病杂志,2021,37(7):632-635.
[27] Empana JP,Boulanger CM,Tafflet M,et al.Microparticles and sudden cardiac death due to coronary occlusion.The TIDE(Thrombus and Inflammation in sudden DEath)study[J].Eur Heart J Acute Cardiovasc Care,2015,4(1):28-36.
[28] Wang B,Li T,Han X,et al.The level of circulating microparticles in patients with coronary heart disease:a systematic review and meta-analysis[J].J Cardiovasc Transl Res,2020,13(5):702-712.
[29] Zhang Y,Cheng J,Chen F,et al.Circulating endothelial microparticles and miR-92a in acute myocardial infarction[J].Biosci Rep,2017,37(2).
[30] Berezin AE,Kremzer AA,Samura TA,et al.Altered signature of apoptotic endothelial cell-derived microvesicles predicts chronic heart failure phenotypes[J].Biomark Med,2019,13(9):737-750.
[31] Sinning JM,Jansen F,Hammerstingl C,et al.Circulating microparticles decrease after cardiac stress in patients with significant coronary artery stenosis[J].Clin Cardiol,2016,39(10):570-577.
[32] Hu SS,Zhang HG,Zhang QJ,et al.Small-size circulating endothelial microparticles in coronary artery disease[J].PLoS One,2014,9(8):e104528.
[33] Lin ZB,Ci HB,Li Y,et al.Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction[J].J Transl Med,2017,15(1):4.
[34] Berezin AE,Kremzer AA,Martovitskaya YV,et al.Pattern of circulating endothelial-derived microparticles among chronic heart failure patients with dysmetabolic comorbidities:The impact of subclinical hypothyroidism[J].Diabetes Metab Syndr,2016,10(1):29-36.
[35] Wang Y,Zhang L,Li Y,et al.Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium[J].Int J Cardiol,2015,192:61-69.
[36] Giannopoulos G,Vrachatis DA,Oudatzis G,et al.Circulating erythrocyte microparticles and the biochemical extent of myocardial injury in ST elevation myocardial infarction[J].Cardiology,2017,136(1):15-20.
[37] Chiva-Blanch G,Bratseth V,Ritschel V,et al.Monocyte-derived circulating microparticles(CD14+,CD14+/CD11b+ and CD14+/CD142+)are related to long-term prognosis for cardiovascular mortality in STEMI patients[J].Int J Cardiol,2017,227:876-881.
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