皮肤胆固醇含量与冠状动脉病变严重程度的相关性研究

孔祥勇; 倪敬书; 邱广泉; 王贻坤; 马礼坤; 董美丽

doi:10.13201/j.issn.1001-1439.2021.12.006

皮肤胆固醇含量与冠状动脉病变严重程度的相关性研究

- 1. 中国科学技术大学附属第一医院(安徽省立医院)心内科中国科学院合肥物质科学研究院安徽光学精密机械研究所安徽省医用光学诊疗技术与装备工程实验室(合肥, 230001);
- 2. 皖江新兴产业技术发展中心安徽省生物医学光学仪器工程技术研究中心
基金项目:
中国科学院科技服务网络计划(No:KFJ-STS-QYZD-184)

安徽省科技重大专项(No:201903a07020027)

国家自然科学基金面上项目(No:81870192)

详细信息

通讯作者: 马礼坤,E-mail:lkma@ustc.edu.cn

中图分类号: R541.4

收稿日期: 2021-05-23

修回日期: 2021-06-24

Association between skin cholesterol content and the severity of coronary artery disease

- 1. Department of Cardiology, The First Affiliated Hospital of USTC, Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Provincial Engineering Laboratory for Medical Optical Diagnosis & Treatment Technology and Instrument, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230001, China;
- 2. Wanjiang Center for Development of Emerging Industrial Technology

More Information

Corresponding author: MA Likun, E-mail: lkma@ustc.edu.cn

Received Date: 23 May 2021

Revised Date: 24 June 2021

摘要

摘要: 目的:利用皮肤胆固醇无创检测系统检测不同狭窄程度冠状动脉(冠脉)病变患者的皮肤胆固醇水平,探索皮肤胆固醇含量与冠脉狭窄程度的关系及其在冠心病风险筛查领域中的应用价值。方法:本研究为前瞻性研究,入选中国科学技术大学附属第一医院2020年5月-2021年1月拟诊冠心病的住院患者168例,所有纳入患者近1个月内均未服用任何他汀类及其他降脂药物,住院当天接受皮肤胆固醇含量检测,住院期间完成冠脉造影,通过定量冠脉造影系统(QCA)评估冠脉狭窄严重程度,根据患者的基本临床信息,计算患者的弗明汉评分,分析皮肤胆固醇含量与冠脉狭窄严重程度以及弗明汉评分之间的相关性。结果:皮肤胆固醇含量随着冠脉狭窄严重程度的增加而增加;弗明汉评分超过10%的人群皮肤胆固醇含量显著高于弗明汉评分低于10%的人群;总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平与皮肤胆固醇含量没有显著的相关性。结论:皮肤胆固醇含量与冠脉狭窄严重程度以及弗明汉评分呈正相关,提示皮肤胆固醇含量在冠心病风险筛查领域中的应用前景良好。
- 冠心病 /
- 皮肤胆固醇 /
- 狭窄 /
- 筛查
Abstract: Objective: To explore the relationship between skin cholesterol content and the severity of coronary artery disease and its application in coronary heart disease screening.Methods: A total of 168 inpatients with suspected coronary heart disease diagnosed in the First Affiliated Hospital of the University of Science and Technology of China from May 2020 to January 2021 were enrolled in this prospective study. All the included patients did not take any statins or other lipid-lowering drugs in the past month, the skin cholesterol content was detected on the day of hospitalization, and the severity of coronary artery stenosis was assessed through the quantitative coronary angiography system(QCA). Framingham risk score was calculated based on the patients' basic and clinical information. The correlation between skin cholesterol content and severity of coronary artery stenosis and Framingham risk score was assessed.Results: The skin cholesterol content increased with the severity of coronary artery stenosis. The skin cholesterol content in people with Framingham score more than 10 % was significantly higher than that in people with Framingham score less than 10%. There was no significant correlation between the levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), and high density lipoprotein cholesterol(HDL-C) and skin cholesterol content.Conclusion: Skin cholesterol content is positively correlated with the severity of coronary artery stenosis and Framingham score, suggesting that the non-invasive skin cholesterol detection may potentially be used as a risk assessment tool for coronary heart disease screening.
- skin cholesterol /
- coronary heart disease /
- stenosis /
- screening

HTML全文

参考文献(22)

[1]	Kimura K,Kimura T,Ishihara M,et al.JCS 2018Guideline on diagnosis and treatment of acute coronary syndrome[J].Circ J,2019,83(5):1085-1196.
[2]	中国心血管健康与疾病报告2019[J].心肺血管病杂志,2020,39(10):1157-1162.
[3]	Case BC,Waksman R.Coronary heart disease:have we reached a plateau in primary prevention?[J].J Am Heart Assoc,2020,9(7):e04963.
[4]	Marcos-Forniol E,Corbella E,Pinto X.Mortality and compliance with secondary prevention goals of ischaemic heart disease in patients>/=70 years:observational study[J].Med Clin(Barc),2020,154(7):243-247.
[5]	Joo KM,Hwang JH,Bae S,et al.Relationship of ceramide-,and free fatty acid-cholesterol ratios in the stratum corneum with skin barrier function of normal,atopic dermatitis lesional and non-lesional skins[J].J Dermatol Sci,2015,77(1):71-74.
[6]	Bhattacharya N,Sato WJ,Kelly A,et al.Epidermal lipids:key mediators of atopic dermatitis pathogenesis[J].Trends Mol Med,2019,25(6):551-562.
[7]	Wertz PW.Lipids and the permeability and antimicrobial barriers of the skin[J].J Lipids,2018:5954034.
[8]	Wohlrab J,Gebert A,Neubert RHH.Lipids in the skin and Ph[J].Curr Probl Dermatol,2018,54:64-70.
[9]	Uche LE,Gooris GS,Bouwstra JA,et al.Barrier capability of skin lipid models:effect of ceramides and free fatty acid composition[J].Langmuir,2019,35(47):15376-15388.
[10]	Sochorova M,Audrlicka P,Cervena M,et al.Permeability and microstructure of cholesterol-depleted skin lipid membranes and human stratum corneum[J].JColloid Interface Sci,2019,535:227-238.
[11]	Stein JH,Tzou WS,DeCara JM,et al.Usefulness of increased skin cholesterol to identify individuals at increased cardiovascular risk(from the Predictor of Advanced Subclinical Atherosclerosis study)[J].Am JCardiol,2008,101(7):986-991.
[12]	Tzou WS,Mays ME,Korcarz CE,et al.Skin cholesterol content identifies increased carotid intima-media thickness in asymptomatic adults[J].Am Heart J,2005,150(6):1135-1139.
[13]	Sprecher DL,Pearce GL.Skin cholesterol adds to Framingham risk assessment[J].Am Heart J,2006,152(4):694-696.
[14]	Sprecher DL,Pearce GL.Elevated skin tissue cholesterol levels and myocardial infarction[J].Atherosclerosis,2005,181(2):371-373.
[15]	Vaidya D,Ding J,Hill JG,et al.Skin tissue cholesterol assay correlates with presence of coronary calcium[J].Atherosclerosis,2005,181(1):167-173.
[16]	吴鹏,倪敬书,洪海鸥,等.基于荧光光谱法的皮肤胆固醇快速无创检测技术[J].中国激光,2021,48(3):0307002.
[17]	Libby P,Buring JE,Badimon L,et al.Atherosclerosis[J].Nat Rev Dis Primers,2019,5(1):56.
[18]	Pothineni NVK,Subramany S,Kuriakose K,et al.Infections,atherosclerosis,and coronary heart disease[J].Eur Heart J,2017,38(43):3195-3201.
[19]	王耀羚,戚本玲,白丽娟,等.基于肥胖与肌量划分的人体成分类型与动脉硬化的关系研究[J].临床心血管病杂志,2020,36(10):906-913.
[20]	杨晓,谢勇,徐日新,等.血浆致动脉硬化指数对早发冠心病的预测作用[J].临床心血管病杂志,2020,36(11):1000-1003.
[21]	Jahangiry L,Farhangi MA,Rezaei F.Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome[J].JHealth Popul Nutr,2017,36(1):36.
[22]	Petruzzo M,Reia A,Maniscalco GT,et al.The Framingham cardiovascular risk score and 5-year progression of multiple sclerosis[J].Eur J Neurol,2021,28(3):893-900.