Research progress of iron oxide magnetic nanoparticles in cardiovascular biocompatibility
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摘要: 近20余年来，磁性氧化铁纳米颗粒(IONPs)广泛应用于心血管领域，如磁靶向药物递送、细胞高效磁转染、药物捕获、干细胞移植示踪、心脏磁共振对比剂等，展示了广阔的应用前景和潜在的临床应用价值。然而，IONPs的毒性正日益引起关注，严重阻碍了其在心血管领域的临床转化。本综述总结了IONPs的心血管毒性作用和可能机制，并初步探讨如何改善IONPs的安全性。Abstract: For the past two decades, iron oxide magnetic nanoparticles(IONPs) has been widely used in the cardiovascular field, such as magnetic drug delivery and capture, magnetic cell transfection, stem cell transplantation tracer, MRI contrast agent and so on. However, because of the toxicity and biocompatibility, IONPs'clinical application potentiality fails to fully demonstrate. In this review, we briefly summarize the research progress of IONPs side effects in the cardiovascular field, its potential mechanism and improved methods. This review will be able to provide a new strategy for the clinical use of IONPs.
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