One case report of neuroblastoma complicated with catecholamine cardiomyopathy in children
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摘要: 报道1例儿童神经母细胞瘤合并儿茶酚胺心肌病并进行文献复习。3岁10个月患儿，起病隐匿，以慢性心功能不全为主要表现，合并高血压，完善心脏彩超、血及尿儿茶酚胺、腹部影像学及术后病理组织检查，确诊左肾上腺节细胞神经母细胞瘤(结节型)。神经母细胞瘤长期分泌过多儿茶酚胺，导致儿茶酚胺心肌病及高血压。儿童儿茶酚胺心肌病较为罕见。对于以心功能不全起病，尤其合并高血压患儿，应警惕肿瘤源性儿茶酚胺心肌病，应早期进行相关检查，改善心功能，并尽早手术，以改善预后。Abstract: One case of neuroblastoma with catecholamine cardiomyopathy in children was reported and related literatures were reviewed. A 3-year and 10-month old child with insidious onset, chronic cardiac insufficiency as the main manifestation, combined with hypertension. Through cardiac color Doppler ultrasound, blood and urine catecholamines, abdominal imaging and postoperative pathological examination, the final diagnosis of "left adrenal gland" ganglion cell neuroblastoma(nodular type). Neuroblastoma long-term secretion of excessive catecholamines leads to catecholamine cardiomyopathy and hypertension. Catecholamine cardiomyopathy in children is rare. For onset of cardiac insufficiency, especially with hypertension in children, tumor-derived catecholamine cardiomyopathy should be considered, relevant examinations should be carried out early to improve cardiac function and early surgery to improve prognosis.
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Key words:
- catecholamine cardiomyopathy /
- hypertension /
- neuroblastoma /
- children
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图 5 肿瘤大部分呈不同成熟阶段的神经节细胞(箭头所示)
Figure 5. Ganglion cells at various stages of maturation(arrows)are seen in most tumors
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[1] Kumar A, Pappachan JM, Fernandez CJ. Catecholamine-induced cardiomyopathy: an endocrinologist's perspective[J]. Rev Cardiovasc Med, 2021, 22(4): 1215-1228. doi: 10.31083/j.rcm2204130
[2] 陈哲, 殷洪山, 齐琪, 等. 以急性心肌损伤为首发表现的嗜铬细胞瘤1例[J]. 临床心血管病杂志, 2021, 37(5): 492-494. doi: 10.13201/j.issn.1001-1439.2021.05.020
[3] 贾静静, 韩延辉, 王红雷. 以腹痛为首发症状的嗜铬细胞瘤1例[J]. 临床心血管病杂志, 2021, 37(8): 780-782. doi: 10.13201/j.issn.1001-1439.2021.08.022
[4] de Lima-Seolin BG, Nemec-Bakk A, Forsyth H, et al. Bucindolol modulates cardiac remodeling by attenuating oxidative stress in h9c2 cardiac cells exposed to norepinephrine[J]. Oxid Med Cell Longev, 2019, 2019: 6325424.
[5] Thakur A, Alam MJ, Ajayakumar MR, et al. Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation[J]. Redox Biol, 2015, 5: 243-252. doi: 10.1016/j.redox.2015.05.005
[6] Du Y, Demillard LJ, Ren J. Catecholamine-induced cardiotoxicity: A critical element in the pathophysiology of stroke-induced heart injury[J]. Life Sci, 2021, 287: 120106. doi: 10.1016/j.lfs.2021.120106
[7] Gordan R, Gwathmey JK, Xie LH. Autonomic and endocrine control of cardiovascular function[J]. World J Cardiol, 2015, 7(4): 204-214. doi: 10.4330/wjc.v7.i4.204
[8] Nakagawara A, Li Y, Izumi H, et al. Neuroblastoma[J]. Jpn J Clin Oncol, 2018, 48(3): 214-241. doi: 10.1093/jjco/hyx176
[9] 夏波, 俞钢, 洪淳, 等. 胎儿神经母细胞瘤10例临床分析[J]. 中华实用儿科临床杂志, 2018, 33(8): 623-624. doi: 10.3760/cma.j.issn.2095-428X.2018.08.017
[10] Inoue T, Ito Y, Nakamura T, et al. A catecholamine-secreting neuroblastoma leading to hydrops fetalis[J]. J Perinatol, 2014, 34(5): 405-407. doi: 10.1038/jp.2014.19
[11] Kato M, Hirata S, Kikuchi A, et al. Neuroblastoma presenting with dilated cardiomyopathy[J]. Pediatr Blood Cancer, 2008, 50(2): 391-392. doi: 10.1002/pbc.21065
[12] Lee YH, Lee HD, Lee YA, et al. Ganglioneuroblastoma presenting as dilated cardiomyopathy[J]. Arch Dis Child, 2003, 88(2): 162-164. doi: 10.1136/adc.88.2.162
[13] Duhil de Bénazé G, Iserin F, Durand P, et al. A dilated cardiomyopathy revealing a neuroblastoma: which link?[J]. J Pediatr Hematol Oncol, 2016, 38(7): e251-253. doi: 10.1097/MPH.0000000000000659
[14] 彭力, 曾赛珍, 王涛, 等. 以心源性休克起病的儿茶酚胺心肌病一例并文献复习[J]. 中国小儿急救医学, 2020, 27(6): 473-476. doi: 10.3760/cma.j.issn.1673-4912.2020.06.016
[15] Kwok SY, Cheng FW, Lo AF, et al. Variants of cardiomyopathy and hypertension in neuroblastoma[J]. J Pediatr Hematol Oncol, 2014, 36(3): e158-161. doi: 10.1097/MPH.0b013e318290c628
[16] Joseph T, Olivier B, Magnier S, et al. Cardiomyopathy induced by catecholamines in neuroblastoma[J]. Arch Pediatr, 1997, 4(1): 32-35. doi: 10.1016/S0929-693X(97)84303-5
[17] Rosti L, Festa P, Corbetta C. Rapid reversal of dilated cardiomyopathy following removal of neuroblastoma[J]. Cardiol Young, 1999, 9(5): 519-521. doi: 10.1017/S1047951100005473
[18] Sendo D, Katsuura M, Akiba K, et al. Severe hypertension and cardiac failure associated with neuroblastoma: a case report[J]. J Pediatr Surg, 1996, 31(12): 1688-1690. doi: 10.1016/S0022-3468(96)90051-2
[19] Singh HR, Paules M, Forbes TJ, et al. Reversible dilated cardiomyopathy and neuroblastoma[J]. J Pediatr, 2005, 147(2): 271. doi: 10.1016/j.jpeds.2004.12.030
[20] Madre C, Orbach D, Baudouin V, et al. Hypertension in childhood cancer: a frequent complication of certain tumor sites[J]. J Pediatr Hematol Oncol, 2006, 28(10): 659-664. doi: 10.1097/01.mph.0000212995.56812.bb
[21] Casey RT, Challis BG, Pitfield D, et al. Management of an acute catecholamine-induced cardiomyopathy and circulatory collapse: a multidisciplinary approach[J]. Endocrinol Diabetes Metab Case Rep, 2017, 2017: 110.
[22] Salathe M, Weiss P, Ritz R. Rapid reversal of heart failure in a patient with phaeochromocytoma and catecholamine-induced cardiomyopathy who was treated with captopril[J]. Br Heart J, 1992, 68(5): 112.
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