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摘要: 非酒精性脂肪肝病(NAFLD)是目前世界上最常见的肝脏和代谢疾病，最新证据表明，NAFLD与心律失常的风险密切相关，独立于其他常规的心脏代谢合并症。机制研究表明，与NAFLD相关的病理生理改变可能潜在地引发心脏的结构、电生理和自主神经重构，促进心律失常的发生。然而，其导致的患病率激增却未受到重视。本文阐述了NAFLD与心房颤动、室性心律失常及心脏传导缺陷疾病相关性的临床证据和潜在的病理生理机制，强调NAFLD可能是心律失常发生发展的独立危险因素和潜在驱动力。Abstract: Non-……alcoholic fatty liver disease(NAFLD) is the most common liver and metabolic disease worldly. Emerging evidences suggest that NAFLD is strongly associated with the risk of cardiac arrhythmias, independent of other conventional cardiometabolic comorbidities. Mechanistic studies imply that pathophysiological alterations associated with NAFLD may trigger structural, electrophysiological, and autonomic remodeling of the heart, promoting the development of arrhythmias. However, little attention has been paid to the pathophysiological association between NAFLD and cardiac arrhythmias. This comment describes the clinical evidence and potential pathophysiological mechanisms underlying the association of NAFLD with atrial fibrillation, ventricular arrhythmias, and cardiac conduction defect disease, highlighting that NAFLD may be an independent risk factor and a potential driver for the development of arrhythmias.
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