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摘要: 尽管传统外科手术对二尖瓣疾病的治疗已非常成熟，但手术创伤较大、体外循环以及术中心肌缺血再灌注损伤等因素导致高龄高风险患者无法耐受。近年来，经导管二尖瓣置换术(transcatheter mitral valve replacement，TMVR)的积极发展让这类患者迎来曙光。TMVR通过微创介入途径即可完成手术治疗。目前，已有多种二尖瓣介入瓣膜进入大范围临床试验阶段，相关研究的初期结果良好，瓣膜安全性和有效性相对乐观，但TMVR仍面临诸多困难和挑战。本文就TMVR的研究进展和应用现状进行综述。Abstract: Although the treatments of mitral valve diseases by traditional surgery are well developed, severe trauma, extracorporeal circulation, and intraoperative myocardial-ischemia reperfusion injury cause the failure of elderly and high-risk patients to receive surgical treatments. In recent years, the thriving development of transcatheter mitral valve replacement(TMVR) has brought hope to such patients. TMVR can be performed by minimally invasive intervention. Nowadays, a variety of mitral interventional valves are currently in extensive clinical trials. The safety and efficacy of prosthetic valves are optimistic. The initial results of relevant studies are positive. However, there are still many problems and challenges with TMVR. This article reviews the research progress and application status of TMVR.
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