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摘要: 动脉粥样硬化性心血管疾病(atherosclerotic cardiovascular disease，ASCVD)是引起心血管患者死亡的首要原因，在我国呈逐年上升趋势。已有证据表明，口腔微生物失调所致的牙周疾病可通过全身系统性炎症反应促进ASCVD的发展，但其发生机制及潜在关系目前尚不清楚。因此，本文就口腔微生物和ASCVD的关系，以及口腔微生物失调导致ASCVD的病理生理机制进行阐述，并讨论该领域目前面临的挑战和未来发展方向。
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关键词:
- 口腔微生物组 /
- 动脉粥样硬化性心血管疾病 /
- 菌群失调 /
- 牙龈卟啉单胞菌
Abstract: Atherosclerotic cardiovascular disease is the leading cause of death in cardiovascular patients, which showing an increasing trend year by year in China. There are evidences that periodontal disease caused by oral microbial imbalance can promote the development of ASCVD through systemic inflammatory response, but the mechanism and potential relationship are currently unclear. In this review, the relationship between oral dysbiosis and ASCVD, and the pathophysiological mechanisms of ASCVD caused by oral dysbiosis are elaborated. In addition, the current challenges and future directions of this field are discussed. -
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