Relationship between the ratio of triglyceride high density lipoprotein cholesterol and the risk of hypertension and diabetes in the elder people
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摘要: 目的 探讨老年人群中甘油三酯高密度脂蛋白胆固醇比值(TG/HDL-C)与高血压及糖尿病患病风险的关系。方法 从三明市基础公共卫生系统中选取参与2023年健康体检的263 859例年龄60岁及以上人群，按照TG/HDL-C基线水平的五分位数将人群分为5组，采用回归分析研究TG/HDL-C与高血压和糖尿病患病风险的关联性。结果 高血压患病率为47.6%，糖尿病患病率为15.1%，高血压和糖尿病共病患病率为10.5%，女性比例为52.7%。TG/HDL-C升高与高血压、糖尿病及高血压和糖尿病共病患病风险增加密切相关。TG/HDL-C最高五分位数组具有较高的高血压、糖尿病及高血压和糖尿病共病患病风险。结论 在老年人群中，TG/HDL-C升高与高血压及糖尿病患病率增加密切相关，控制TG/HDL-C可能对高血压糖尿病的防治具有重要意义。
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关键词:
- 老年人 /
- 甘油三酯高密度脂蛋白胆固醇比值 /
- 高血压 /
- 糖尿病
Abstract: Objective To explore the relationship between triglyceride high density lipoprotein cholesterol ratio(TG/HDL-C) and the risk of hypertension and diabetes in the elderly.Methods The 263 859 people aged 60 years and above who participated in the physical examination in 2023 were selected from the basic public health system of Sanming City, and were divided into five groups according to the quintile of TG/HDL-C baseline level. Regression analysis was used to study the correlation between TG/HDL-C and the risk of hypertension and diabetes.Results In this study, the prevalence of hypertension was 47.6%, the prevalence of diabetes was 15.1%, the prevalence of hypertension and diabetes was 10.5%, and the proportion of women was 52.7%. The increase of TG/HDL-C is closely related to hypertension, diabetes and the increased risk of hypertension and diabetes comorbidity. TG/HDL-C highest quintile array has a higher risk of hypertension, diabetes, hypertension and diabetes comorbidity.Conclusion In the elderly, the increase of TG/HDL-C is closely related to the increase of the prevalence of hypertension and diabetes. The control of TG/HDL-C may be of great significance for the prevention and treatment of hypertension and diabetes. -
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图 2 TG/HDL-C在不同性别、年龄和BMI亚组中的分布
Figure 2. Distribution of TG/HDL-C in different gender, age, and BMI subgroups
表 1 受试者基线临床特征
Table 1. Baseline characteristics of the study population
例(%), X±S 临床特征 TG/HDL-C P 最低五分位数组 第二五分位数组 第三五分位数组 第四五分位数组 最高五分位数组 例数 52 774(20.0) 52 764(20.0) 52 772(20.0) 52 776(20.0) 52 773(20.0) 女性 25 903(49.1) 27 211(51.6) 28 296(53.6) 28 761(54.5) 28 810(54.6) < 0.001 年龄/岁 74.1±6.87 74.0±7.02 73.6±7.02 73.2±6.97 72.3±6.86 < 0.001 腰围/cm 77.4±8.74 80.3±8.98 82.4±8.99 84.2±8.95 86.0±8.67 < 0.001 BMI/(kg/m2) 21.8±3.05 22.7±3.22 23.4±3.26 24.1±3.25 24.7±3.14 < 0.001 收缩压/mmHg 135.5±18.8 136.8±18.8 137.4±18.2 138.4±18.3 139.5±18.2 < 0.001 舒张压/mmHg 78.5±10.3 79.3±10.3 79.9±10.2 80.5±10.2 81.5±10.2 < 0.001 心率/(次/min) 70.0±12.1 71.0±12.1 71.7±12.0 72.1±11.8 73.2±11.8 < 0.001 目前吸烟 10 995(20.8) 10 220(19.4) 9 778(18.5) 9 450(17.9) 9 473(18.0) < 0.001 高血压病 19 453(36.9) 22 575(42.8) 25 362(48.1) 27 663(52.4) 30 550(57.9) < 0.001 糖尿病 4 499(8.53) 6 083(11.5) 7 684(14.6) 9 409(17.8) 12 245(23.2) < 0.001 血糖/(mmol/L) 5.45±1.46 5.61±1.58 5.77±1.76 5.99±1.99 6.39±2.47 < 0.001 总胆固醇/(mmol/L) 4.97±1.12 5.05±1.16 5.12±1.19 5.21±1.21 5.28±1.24 < 0.001 TG/(mmol/L) 0.73±0.21 1.04±0.23 1.35±0.30 1.78±0.40 3.19±1.47 < 0.001 HDL-C/(mmol/L) 1.99±0.77 1.63±0.35 1.47±0.31 1.32±0.27 1.15±0.27 < 0.001 
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表 2 高血压和(或)糖尿病与TG/HDL-C比值的关系
Table 2. Relationship between hypertension and/or diabetes and TG/HDL-C
模型 未校正模型 校正模型 OR(95%CI) P值 OR(95%CI) P值 高血压 1.28(1.27~1.29) < 0.001 1.10(1.09~1.11) < 0.001 糖尿病 1.33(1.32~1.34) < 0.001 1.09(1.07~1.10) < 0.001 高血压合并糖尿病 1.35(1.33~1.36) < 0.001 1.13(1.12~1.14) < 0.001 注：校正模型中的校正因素为性别、年龄、BMI、收缩压、心率、吸烟、血糖及所属县级。
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表 3 高血压和(或)糖尿病与TG/HDL-C不同分组之间的关系
Table 3. Relationship between hypertension and/or diabetes and quintiles of TG/HDL-C
模型 高血压 糖尿病 高血压合并糖尿病 OR(95%CI) P OR(95%CI) P OR(95%CI) P 最低五分位数组 参考 参考 参考 第二五分位数组 1.07(1.04~1.10) < 0.001 1.14(1.09~1.19) < 0.001 1.19(1.13~1.25) < 0.001 第三五分位数组 1.17(1.14~1.20) < 0.001 1.26(1.20~1.32) < 0.001 1.36(1.30~1.44) < 0.001 第四五分位数组 1.25(1.21~1.28) < 0.001 1.36(1.30~1.42) < 0.001 1.54(1.47~1.62) < 0.001 最高五分位数组 1.40(1.36~1.44) < 0.001 1.47(1.41~1.54) < 0.001 1.74(1.66~1.83) < 0.001 注：校正模型中的校正因素为性别、年龄、BMI、收缩压、心率、吸烟、血糖及所属县级。
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表 4 其他因素与高血压和(或)糖尿病的关系
Table 4. The relationship of hypertension and/or diabetes with other risk factors
模型 高血压(125 603例) 糖尿病(39 920例) 高血压合并糖尿病(27 578例) OR(95%CI) P OR(95%CI) P OR(95%CI) P 性别 男性 1.09(1.08~1.11) < 0.001 1.08(1.06~1.09) < 0.001 1.12(1.10~1.14) < 0.001 女性 1.10(1.09~1.11) < 0.001 1.08(1.06~1.10) < 0.001 1.12(1.11~1.14) < 0.001 年龄 < 75岁 1.09(1.08~1.10) < 0.001 1.09(1.07~1.10) < 0.001 1.11(1.10~1.13) < 0.001 75~90岁 1.10(1.08~1.12) < 0.001 1.14(1.12~1.17) < 0.001 1.15(1.13~1.17) < 0.001 ≥90岁 1.06(0.98~1.15) 0.13 1.11(0.98~1.26) 0.091 1.09(0.96~1.24) < 0.001 BMI < 24 kg/m2 1.11(1.10~1.13) < 0.001 1.12(1.10~1.14) < 0.001 1.17(1.15~1.19) < 0.001 24~28 kg/m2 1.08(1.06~1.09) < 0.001 1.05(1.03~1.06) < 0.001 1.09(1.07~1.11) < 0.001 ≥28 kg/m2 1.06(1.04~1.09) < 0.001 1.02(0.99~1.05) 0.22 1.04(1.01~1.08) 0.005 吸烟 否 1.10(1.09~1.11) < 0.001 1.08(1.07~1.09) < 0.001 1.12(1.11~1.14) < 0.001 过去 1.10(1.05~1.16) < 0.001 1.09(1.02~1.16) 0.007 1.12(1.05~1.20) < 0.001 现在 1.11(1.09~1.13) < 0.001 1.09(1.06~1.12) < 0.001 1.13(1.10~1.17) < 0.001 注：校正模型中的校正因素为性别、年龄、BMI、收缩压、心率、吸烟、血糖及所属县级。年龄中位数为72岁，BMI中位数为23.2 kg/m2。
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