慢性肾脏病血管钙化调控机制的最新研究进展

熊琳; 李怡; 王莉; 李贵森

doi:10.13201/j.issn.1001-1439.2025.04.003

慢性肾脏病血管钙化调控机制的最新研究进展

- 1.
  电子科技大学医学院(成都，610054)
- 2.
  四川省人民医院肾脏内科
- 3.
  四川省肾脏疾病临床研究中心
基金项目:
国家自然科学基金(No：U21A20349)；四川省科技厅项目(No：2023ZYD0170)

详细信息

通讯作者: 李贵森，E-mail：guisenli@163.com

中图分类号: R543

收稿日期: 2024-11-11

刊出日期: 2025-04-13

Recent advances in the regulatory mechanism of vascular calcification in chronic kidney disease

- 1.
  School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China
- 2.
  Department of Nephrology, Sichuan Provincial People's Hospital
- 3.
  Sichuan Clinical Research Centre for Kidney Diseases

More Information

Corresponding author: LI Guisen, E-mail: guisenli@163.com

Received Date: 11 November 2024

Publish Date: 13 April 2025

摘要

摘要: 血管钙化是慢性肾脏病(chronic kidney disease，CKD)最常见的并发症之一，显著增加了患者的心血管疾病发生率和病死率。目前，血管钙化被认为是一个活跃的、受到高度调控的、细胞介导的主动过程。血管平滑肌细胞(vascular smooth muscle cells，VSMCs)从收缩表型向成骨样细胞转分化是导致血管钙化的关键环节。最新的研究揭示线粒体异常、表观遗传学修饰、铁死亡、肠道菌群失调以及补体系统异常激活等一系列因素，与CKD血管钙化和VSMCs的成骨转分化密切相关。本文重点就近5年来CKD血管钙化调控机制的最新研究进展进行综述，以期为进一步研究CKD血管钙化的防治靶点和干预措施提供理论依据。
- 慢性肾脏病 /
- 血管钙化 /
- 血管平滑肌细胞 /
- 成骨转分化 /
- 调控机制
Abstract: Vascular calcification is one of the most common complications of chronic kidney disease(CKD) and significantly increases the incidence and mortality of cardiovascular disease. Currently, vascular calcification is recognized as a complex, highly regulated, cell-mediated active process. The trans-differentiation of vascular smooth muscle cells(VSMCs) from a contractile phenotype to osteoblast-like cells is a key component leading to vascular calcification. Recent studies reveal that a range of factors, including mitochondrial abnormalities, epigenetic modifications, ferroptosis, intestinal flora dysbiosis, and aberrant activation of the complement system, are closely associated with vascular calcification and osteogenic trans-differentiation of VSMCs in CKD. This article focuses on the latest research progress on the regulatory mechanisms of CKD vascular calcification in the past five years, aiming to provide a theoretical basis for further research on the prevention and treatment targets and interventions of CKD vascular calcification.
- chronic kidney disease /
- vascular calcification /
- vascular smooth muscle cells /
- osteogenic trans-differentiation /
- regulatory mechanism

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