Research progress on the predictive factors of renal denervation in the treatment of hypertension
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摘要: 去肾神经术(renal denervation，RDN)作为治疗高血压的新型方法，因其有效性、安全性且持久的降压特性而备受关注。近年来，关于RDN应答预测因子的研究方兴未艾。现有研究表明，基线血压、基线心率、肾素-血管紧张素-醛固酮系统(RAAS)活性、动脉硬化程度参数、合并高心血管风险疾病、个体特征、生物标志物、免疫炎症等指标均可作为RDN的预测因子。然而，随着临床实践和研究结果的不断推陈出新，RDN的适应证范围也在不断改变。本文综述了RDN治疗高血压预测因子的最新研究成果，旨在为临床选择RDN预测指标提供参考。Abstract: Renal denervation (RDN), as a novel modality for the treatment of hypertension, has garnered significant attention due to its efficacy, safety, and sustained antihypertensive properties. In recent years, research on the predictive factors of RDN response has been burgeoning. Current studies have indicated that indicators such as baseline blood pressure, resting heart rate, renin-angiotensin-aldosterone system (RAAS) activity, parameters of the degree of arteriosclerosis, concurrent high cardiovascular risk diseases, individual characteristics, biomarkers, and immune inflammation can all serve as predictors of RDN. Nevertheless, with the continuous advancement of clinical practice and research outcomes, the indication scope of RDN is also constantly evolving. This review summarizes the latest advances in the research of predictive factors for RDN efficacy in hypertension management, aiming to provide a reference for the clinical identification and selection of suitable candidates for RDN therapy.
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Key words:
- renal denervation /
- hypertension /
- predictive factors
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