Ghrelin与心力衰竭和抑郁障碍的关系

徐素丹; 卢永昕

doi:10.13201/j.issn.1001-1439.2014.07.006

Ghrelin与心力衰竭和抑郁障碍的关系

徐素丹,
卢永昕^,

- 华中科技大学附属协和医院心内科(武汉, 430022)

详细信息

通讯作者: 卢永昕,E-mail:yongxin_lu6@aliyun.com

中图分类号: R541.6

收稿日期: 2013-11-30

Effect of ghrelin in heart failure and depression

XU Sudan,
LU Yongxin^,

- Department of Cardiology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China

More Information

Corresponding author: LU Yongxin, E-mail: yongxin_lu6@aliyun.com

Received Date: 30 November 2013

摘要

摘要: 抑郁障碍在心力衰竭 (心衰) 患者中很常见, 是心衰患者生活质量降低和死亡率增高的独立危险因素。Ghrelin是一种新型的生长激素释放肽, 具有刺激食欲、调节能量代谢, 抑制心肌细胞和内皮细胞凋亡、拮抗心肌重构, 改善心脏功能及调节睡眠、情绪的作用, 对心衰合并抑郁障碍患者的治疗可能具有潜在的功效。
- ghrelin /
- 心力衰竭 /
- 抑郁障碍
Abstract: Depression in patients with heart failure is strongly associated with poor quality of life and high mortality and morbidity.Ghrelin is a novel growth hormone-releasing peptide, which has regulatory effects on appetite and energy metabolism, and cyto-protective effect on apoptosis of cardiomyocytes and endothelial cells to improve cardiac function.It also influences sleep and has antidepressant-like effects.Ghrelin may be a potential therapeutic approach for heart failure patients with depression.
- ghrelin /
- heart failure /
- depression

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参考文献(31)

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