替格瑞洛对急性冠状动脉综合征患者经皮冠状动脉介入术后血小板聚集功能及预后的影响

陈晖; 闫振富

doi:10.13201/j.issn.1001-1439.2015.05.005

替格瑞洛对急性冠状动脉综合征患者经皮冠状动脉介入术后血小板聚集功能及预后的影响

陈晖,
闫振富

- 郑州大学附属郑州中心医院老年医学科心血管内科病区(郑州, 450007)

详细信息

作者简介:
陈晖,E-mail:chenhuizzs@163.com

中图分类号: R541.4

收稿日期: 2014-09-09

Impact of ticagrelor on platelet aggregation function and prognosis in patients with acute coronary syndrome after primary percutaneous coronary intervention

- Cardiovascular Department of Internal Medicine, Department of Geriatrics, the Affiliated Hospital of Zhengzhou Center, Zhengzhou University, Zhengzhou, 450007, China

Received Date: 09 September 2014

摘要

摘要: 目的:观察替格瑞洛对急性冠状动脉综合征患者(ACS)经皮冠状动脉介入术(PCI)后血小板聚集功能及预后的影响。方法:选择72例ACS患者随机分为两组:在PCI术及常规治疗基础上,替格瑞洛组36例应用阿司匹林+替格瑞洛抗血小板治疗,氯吡格雷组36例应用阿司匹林+氯吡格雷抗血小板治疗。两组患者均观察治疗6个月。观察两组患者的血小板聚集指标的变化、不良心脏事件及出血事件。结果:服药前两组患者的血小板最大聚集率(MPAR)及P2Y12反应单位差异无统计学意义,具有可比性。服药后各时间点(术前、术后10min,服药后24h,服药后7d)替格瑞洛组患者的MPAR及P2Y12反应单位均显著低于氯吡格雷组(均P<0.01);替格瑞洛组6个月内不良心脏事件发生率显著低于氯吡格雷(χ²=4.5714,P<0.05);两组患者出血事件的发生率差异无统计学意义(χ²=0.1406,P>0.05)。结论:替格瑞洛较氯吡格雷能够更好地拮抗我国人群中ACS患者PCI术后的血小板聚集,降低近期主要不良心血管事件的发生率,且不增加患者出血事件的发生率。
- 急性冠状动脉综合征 /
- 血管成形术,经腔,经皮冠状动脉 /
- 血小板聚集 /
- 替格瑞洛 /
- 氯吡格雷
Abstract: Objective:To study the impact of ticagrelor on platelet aggregation function and prognosis in patients with acute coronary syndrome(ACS) after primary percutaneous coronary intervention(PCI).Method:Seventy-two patients with ACS were randomly divided into two groups on the basis of the PCI surgery and conventional treatment:ticagrelor group(36cases) treated with aspirin plus ticagrelor,clopidogrel group(36cases) treated with aspirin plus clopidogrel.Both groups of patients were treated and observed for 6 months.The changes of platelet aggregation index,adverse cardiac events and bleeding events with patients in two groups were observed.Result:There was no significant difference on the MPAR and P2Y12 reaction unit between two groups before treatment(P>0.05).The MPAR and P2Y12 reaction unit in patients in ticagrelor group were significantly lower than those in clopidogrel group on each time point after taking the medicine(before surgery,10 minutes after operation,24 hours after taking the medicine,7days after taking the medication) (all P<0.01).The rate of adverse cardiac events in ticagrelor group was significantly lower than that in clopidogrel group within 6months(χ²=4.5714,P<0.05);There was no significant difference on the incidence of hemorrhage between the two groups(χ²=0.1406,P>0.05).Conclusion:Ticagrelor can antagonize platelet aggregation better than clopidogrel in patients with ACS after PCI in the population of China,thus reducing the incidence of major adverse cardiac events,and does not increasing the incidence of bleeding events in patients.
- acute coronary syndrome /
- angioplasty,transluminal,percutaneous coronary /
- platelet aggregation /
- ticagrelor /
- clopidogrel

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