ATP结合盒转运子A1基因M883I多态性与动脉粥样硬化易感性的相关性分析

吴玉琴; 陈玲; 杨晓文; 严世荣

doi:10.13201/j.issn.1001-1439.2015.05.013

ATP结合盒转运子A1基因M883I多态性与动脉粥样硬化易感性的相关性分析

- 1 湖北医药学院附属太和医院手术室(湖北十堰, 442000);
- 2湖北医药学院附属太和医院检验科;
- 3 湖北医药学院基础医学院生化教研室

详细信息

作者简介:
严世荣,E-mail:graceyan@163.com

中图分类号: R543.5

收稿日期: 2014-10-11

Meta-analysis:relationship between ATP-binding cassette transporters A1 M883I polymorphism with susceptibility to atherosclerosis

- 1 Operating Room of Taihe Hospital, the first Affiliated Hospital of Hubei University of Medicine, Shiyan, Hubei, 442000, China;
- 2 Clinical Laboratory of Taihe Hospital, the First Affiliated Hospital of Hubei University of Medicine;
- 3 School of Basic Medicine, Hubei University of Medicine

Received Date: 11 October 2014

摘要

摘要: 目的:研究ATP结合盒转运体A1(ABCAl)基因M883I多态性与动脉粥样硬化(AS)的相关性。方法:计算机检索CNKI、万方数据库、VIP及Medline、PubMed、Web of Science数据库,收集中国人群ABCAl基因M833I多态性与AS相关性的病例对照研究或队列研究,检索时间从建库至2014年4月30号。在评价纳入研究质量并提取有效数据后,用Stata12.0软件进行meta分析,计算OR值及95%CI,并评价分析结果的可靠性与稳定性。结果:16篇文献最终纳入研究,累积AS患者4 985例,对照人群14 286例。森林图显示,在高加索人群中,病例组M等位基因频率显著高于I等位基因(OR:0.87,95%CI:0.78~0.96,P<0.05),而在亚洲人群中,中国汉族人群(OR:1.05,95%CI:0.79~1.41,P>0.05)以及其他民族人群M等位基因较I等位基因(OR:1.15,95%CI:0.99~1.33,P>0.05)均没有显著性差异。结论:在高加索人群中,ABCAl基因M883I位点多态性与AS的发生有显著相关性,而与亚洲人群AS的发生则没有相关性。
- 动脉粥样硬化 /
- ABCA1 /
- 多态性 /
- meta分析
Abstract: Objective:To evaluate the association of ABCA1 gene M883Ipolymorphism with the susceptibility to atherosclerosis(AS).Method:Relative literatures were fully searched and screened from CNKI,Wanfang,VIP,Medline,PubMed and Web of Science before April 30,2014.The pooled OR and its 95%CI were calculated,and the evaluation of the reliability and stability of the results were performed through meta-analysis by Stata12.0software.Result:Sixteen literatures containing 4 985 cases and 14 286 controls were included,results from meta-analysis showed that significant association were observed between the ABCA1 gene M883Ipolymorphism and AS in the population of Caucasians(OR:0.87,95%CI:0.78~0.96,P<0.05),but there was no significant correlation in the Asians,neither in Chinese Han population(OR:1.05,95%CI:0.79~1.41,P<0.05),nor in other ethnic groups(OR:1.15,95%CI:0.99~1.33,P>0.05).Conclusion:There is no correlation between M883 Ipolymorphism at the ABCA1 gene and atherosclerosis in Chinese Han population as well as other ethnic groups in Asia,but a significant correlation in Caucasians.
- ABCA1 /
- polymorphism /
- atherosclerosis /
- meta-analysis

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