Meta-analysis:relationship between ATP-binding cassette transporters A1 M883I polymorphism with susceptibility to atherosclerosis
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摘要: 目的:研究ATP结合盒转运体A1(ABCAl)基因M883I多态性与动脉粥样硬化(AS)的相关性。方法:计算机检索CNKI、万方数据库、VIP及Medline、PubMed、Web of Science数据库,收集中国人群ABCAl基因M833I多态性与AS相关性的病例对照研究或队列研究,检索时间从建库至2014年4月30号。在评价纳入研究质量并提取有效数据后,用Stata12.0软件进行meta分析,计算OR值及95%CI,并评价分析结果的可靠性与稳定性。结果:16篇文献最终纳入研究,累积AS患者4 985例,对照人群14 286例。森林图显示,在高加索人群中,病例组M等位基因频率显著高于I等位基因(OR:0.87,95%CI:0.78~0.96,P<0.05),而在亚洲人群中,中国汉族人群(OR:1.05,95%CI:0.79~1.41,P>0.05)以及其他民族人群M等位基因较I等位基因(OR:1.15,95%CI:0.99~1.33,P>0.05)均没有显著性差异。结论:在高加索人群中,ABCAl基因M883I位点多态性与AS的发生有显著相关性,而与亚洲人群AS的发生则没有相关性。Abstract: Objective:To evaluate the association of ABCA1 gene M883Ipolymorphism with the susceptibility to atherosclerosis(AS).Method:Relative literatures were fully searched and screened from CNKI,Wanfang,VIP,Medline,PubMed and Web of Science before April 30,2014.The pooled OR and its 95%CI were calculated,and the evaluation of the reliability and stability of the results were performed through meta-analysis by Stata12.0software.Result:Sixteen literatures containing 4 985 cases and 14 286 controls were included,results from meta-analysis showed that significant association were observed between the ABCA1 gene M883Ipolymorphism and AS in the population of Caucasians(OR:0.87,95%CI:0.78~0.96,P<0.05),but there was no significant correlation in the Asians,neither in Chinese Han population(OR:1.05,95%CI:0.79~1.41,P<0.05),nor in other ethnic groups(OR:1.15,95%CI:0.99~1.33,P>0.05).Conclusion:There is no correlation between M883 Ipolymorphism at the ABCA1 gene and atherosclerosis in Chinese Han population as well as other ethnic groups in Asia,but a significant correlation in Caucasians.
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Key words:
- ABCA1 /
- polymorphism /
- atherosclerosis /
- meta-analysis
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[1] LLOYD-JONES D, ADAMS R, CARNETHON M, et al. Heart disease and stroke statistics--2009 update:a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee[J]. Circulation, 2009,119:480-486.
[2] SEE R H, CADAY-MALCOLM R A, SINGARAJA R R, et al. Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1(ABCA1)-mediated phospholipid efflux[J]. J Biol Chem, 2002,277:41835-41842.
[3] NEGI S I, BRAUTBAR A, VIRANI S S, et al. A novel mutation in the ABCA1 gene causing an atypical phenotype of Tangier disease[J]. J Clin Lip, 2013,7:82-87.
[4] BOCCHI L, PISCIOTTA L, FASANO T, et al. Multiple abnormally spliced ABCA1 mRNAs caused by a novel splice site mutation of ABCA1 gene in a patient with Tangier disease[J]. Clin Chim Acta Intern J Clin Chem, 2010,411:524-530.
[5] ANDRIKOVICS H, PONGRACZ E, KALINA A, et al. Decreased frequencies of ABCA1 polymorphisms R219K and V771M in Hungarian patients with cerebrovascular and cardiovascular diseases[J]. Cerebrovasc Dis, 2006,21:254-259.
[6] FRIKKE-SCHMIDT R, NORDESTGAARD B G, JENSEN G B, et al. Genetic variation in ABCA1 predicts ischemic heart disease in the general population[J]. Arterioscler Thromb Vasc Biol, 2008,28:180-186.
[7] 郭志刚,吴平生,刘亚洋,等. ABCA1基因R1587K及M883I与血脂及冠心病易感性的关联分析[J].广东医学, 2007,28(3):378-381.
[8] HARADA T, IMAI Y, NOJIRI T, et al. A common Ile 823 Met variant of ATP-binding cassette transporter A1 gene (ABCA1) alters high density lipoprotein cholesterol level in Japanese population[J]. Atherosclerosis, 2003,169:105-112.
[9] 黄健,黄文新,李红艳,等. ABCA1基因I883M多态性与心血管疾病的关系[J],山东医药, 2009,49(9):3-5.
[10] JENSEN M K, MUKAMAL K J, PAI J K, et al. Dietary fat intake modifies the association between a common ABCA1 variant and risk of coronary heart disease among women[J]. Circulation, 2006,113:E323-E323.
[11] 李亚,王玉明,贺勇.腺苷三磷酸结合盒转运体A1基因1883M多态与冠心病的相关性研究[J].四川医学, 2006,27(4):379-380.
[12] 刘新俊. ABCA1基因及HMG-COA还原酶基因单核苷酸多态性与脑梗死的关系研究[D].河北医科大学, 2011.
[13] 毛颖,武贵臻,陈玉岚,等.三磷酸腺苷结合盒转运子A1基因M883I多态性与冠心病的相关性研究[J].中国循环杂志, 2011,26(1):23-26.
[14] MARTIN M, GONZALEZ P, REGUERO J J, et al. ABCA1 polymorphisms and prognosis after myocardial infarction in young patients[J]. Intern J Cardiol, 2006,110:267-268.
[15] PORCHAY-BALDERELLI I, PEAN F, EMERY N, et al. Relationships between common polymorphisms of adenosine triphosphate-binding cassette transporter Al and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus[J]. Metab-Clin Exp, 2009,58:74-79.
[16] 孙屏,薄小萍,郭冬平,等. ABCA1基因多态性与冠心病易感性的关联研究[J].中华心血管病杂志, 2005,33(7):627-630.
[17] TSAI M Y, LI N, SHARRETT A R, et al. Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis[J]. Clin Chem, 2009,55:481-488.
[18] TAN J H, LOW P S, TAN Y S, et al. ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore[J]. Human Genet, 2003;113:106-117.
[19] 王莹. ABCA1基因多态性与血脂及颈动脉粥样硬化斑块的关系[D],浙江大学, 2012.
[20] 张涛,李红兵,王东琦.三磷酸腺苷结合盒转运体A1基因M883I变异与冠心病的关系[J].陕西医学杂志, 2010,39(12):1596-1597.
[21] HUANG C X, ZHANG Y L. The target of regulating the ATP-binding cassette A1 protein (ABCA1):promoting ABCA1-mediated cholesterol efflux in different cells[J]. Curr Pharm Biotechn, 2013,14:623-631.
[22] VAISMAN B L, DEMOSKY S J, STONIK J A, et al. Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis[J]. J Lip Res, 2012,53:158-167.
[23] LIU W, QIN L, YU H, et al. ApoA-I and ABCA1 expression alleviates lipid accumulation in hepatocytes[J]. J Gastroenterol Hepatol, 2014,29:614-622.
[24] BRUNHAM L, TIMMINS J M, PAPE T D, et al. Selective deficiency of hepatic ABCA1 results in increased susceptibility to atherosclerosis[J]. Circulation, 2006,114:146-147.
[25] BOCHEM A E, VAN WIJK D F, HOLLEBOOM A G, et al. ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden[J]. Eur Heart J, 2013,34:286-291.
[26] LI Y, TANG K, ZHOU K, et al. Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease[J]. Mol Biol Rep, 2012, 39:1809-1813.
[27] JIANG Z, ZHOU R, XU C, et al. Genetic variation of the ATP-binding cassette transporter A1 and susceptibility to coronary heart disease[J]. Mol Genet Metabol 2011,103:81-88.
[28] MA X Y, LIU J P, SONG Z Y. Associations of the ATP-binding cassette transporter A1 R219K polymorphism with HDL-C level and coronary artery disease risk:A meta-analysis[J]. Atherosclerosis, 2011,215:428-434.
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