Influence of helicobacter pylori infection on inflammatory cytokines and severity of coronary artery lesions in coronary heart disease
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摘要: 目的:探讨幽门螺杆菌(Hp)感染对冠心病患者血清炎性因子的影响及其与冠状动脉(冠脉)病变严重程度之间的关系。方法:选取行冠脉造影并确诊为冠心病的患者159例为研究对象,采用14C尿素呼气试验测定其Hp感染状况,根据14C尿素呼气试验结果将患者分为Hp感染组和非Hp感染组。采集入选病例所有临床资料,进行冠脉Gensini评分,同时测定其血清高敏C反应蛋白(hs-CRP)、髓过氧化物酶(MPO)和脂蛋白相关磷脂酶A2(Lp-PLA2)水平。结果:冠心病患者中Hp感染者的血清hs-CRP、MPO、Lp-PLA2水平、白细胞计数和Gensini积分均高于非Hp感染者,且随着Hp感染程度的加重,血清hs-CRP、MPO、Lp-PLA2水平、白细胞计数以及Gensini积分亦相应增高。F检验显示,Hp不同感染程度分组血清hs-CRP、MPO、Lp-PLA2水平以及Gensini积分均差异有统计学意义(P<0.01)。多元线性回归分析显示,Hp感染以及血清hs-CRP、MPO、LpPLA2均为冠心病患者冠脉Gensini积分的影响因素。结论:Hp感染可能通过升高血清炎性因子的水平来增加冠脉血管损害程度,从而在冠心病的发生发展中起至关重要的作用。
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关键词:
- 冠心病 /
- 幽门螺杆菌 /
- 髓过氧化物酶 /
- 脂蛋白相关磷脂酶A2 /
- 超敏C-反应蛋白
Abstract: Objective:To explores the influence of helicobacter pylori(Hp) infection on serum inflammatory cytokines levels and severity of coronary artery lesions in patients with coronary heart disease.Method:One hundred and fifty-nine patients with coronary heart disease diagnosed by coronary artery angiography were selected.14 Curea breath test was used to determine the situation of Hp infection.According to the results of 14 Curea breath test,the patients were divided into Hp infection groups and Hp non-infection group.All the subjects' clinical data were collected,the Gensini score was calculate,and serum levels of hs-CRP,MPO and Lp-PLA2 were determined.Result:Levels of hs-CRP,MPO,Lp-PLA2,white blood cell count and Gensini score in Hp infection group were higher than those in Hp non-infection group,and with the Hp infection aggravating,the levels of hsCRP,MPO,Lp-PLA2,white blood cell count and Gensini score also increased.F test showed that differences of the serum levels of hs-CRP,MPO,Lp-PLA2 and Gensini score in the two groups were significant(all P<0.01).Multiple linear regression analysis showed that Hp infection and serum hs-CRP,MPO and Lp-PLA2 levels were the affecting factors of Gensini score.Conclusion:Hp infection may enhance the extent of damage to the coronary vessels by elevating serum inflammatory cytokines levels,which plays a crucial role in the development of coronary heart disease. -
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