骨髓干细胞移植对急性心肌梗死心功能影响的meta分析

贾佳; 晏丽; 胡继宏

doi:10.13201/j.issn.1001-1439.2015.05.015

骨髓干细胞移植对急性心肌梗死心功能影响的meta分析

- 1 甘肃中医学院(兰州, 730000);
- 2 兰州市卫生学校

详细信息

作者简介:
胡继宏,E-mail:hujihonghappy@163.com

中图分类号: R542.2

收稿日期: 2014-09-11

Bone marrow stem cell transplantation for acute myocardial infarction:a meta-analysis

- 1 Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, China;
- 2 Lanzhou Health School〖JP

Received Date: 11 September 2014

摘要

摘要: 目的:探讨骨髓干细胞移植治疗急性心肌梗死心功能的效果。方法:系统检索数据库MEDLINE、EMBASE、Cochrane图书馆、中国知网以及万方数据库。时间为建库到2014年1月。纳入文献用RevMan5.2进行分析。结果:共4篇临床试验(n=218)纳入meta分析。结果显示:与对照组相比,骨髓干细胞移植显著提高了急性心肌梗死患者的左室射血分数(SMD=0.84,95%CI:0.12~1.55,P<0.05)。而移植骨髓干细胞后的心肌梗死面积与注射无干细胞溶液的对照组相比,差异无统计学意义。结论:骨髓干细胞可改善急性心肌梗死后的左室射血分数。
- 心肌梗死 /
- 细胞移植 /
- 左射血分数 /
- 梗死面积
Abstract: Objective:To review the quality of clinical trials and further to evaluate the effectiveness on acute myocardial infarction using bone marrow stem cell transplantation with meta-analysis.Method:We searched MEDLINE database,EMBASE database,Cochrane Library,Chinese HowNet database and Wanfang Medical Data System which deadlined to January 2014,then assessed the quality of study literatures according to the Jadad score ratings and analyzed with RevMan5.2statistical software.Result:A total of 4literatures including 218 patients met the inclusion criteria.Meta-analysis showed that the left ejection fraction in the intervention group using bone marrow stem cell transplantation treatment was significantly higher than that in the control group(SMD=0.84,95%CI:0.12~1.55,P<0.05).But the size of myocardial infarction was not significantly different between two groups.Conclusion:Transplantation of bone marrow stem cells can improve left ejection fraction.
- myocardial infarction /
- cell transplantation /
- left ejection fraction /
- infarct size

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