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摘要: 心房颤动是临床上最常见的快速性心律失常之一,常引起脑卒中、冠心病、心力衰竭、肢体动脉栓塞等严重并发症,是导致患者不良预后的重要因素。外泌体是细胞释放的30~150 nm大小的双层脂质囊泡,携带蛋白质、核酸和脂质等生物活性物质;其作为信息传递的媒介,在细胞间通讯中起着关键作用。近年研究发现外泌体广泛参与心血管疾病的病理生理过程,其与心房颤动的发生发展也关系密切,本文就细胞外囊泡概述、外泌体基本生物学特性以及外泌体在心房颤动中的作用研究进展作一综述。Abstract: Atrial fibrillation is one of the most common tachyarrhythmias in clinical practice. It usually causes severe complications such as stroke, coronary heart disease, heart failure and limb arterial embolism, which is an important factor leading to poor prognosis in patients. Exosome is a bilayer lipid vesicle with a diameter of 30-150 nm released by cells, which carries bioactive substance including proteins, nucleic acids and lipids. As a medium of information transferring, it plays a significant role in intercellular communication. In recent years, it has been discovered that exosome is widely involved in pathophysiological processes of cardiovascular diseases and also closely related to the occurrence and development of atrial fibrillation. This article reviews overview of extracellular vesicles, exosome fundamental biology, as well as research progress on the role of exosome in atrial fibrillation.
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Key words:
- exosome /
- atrial fibrillation /
- microRNA /
- cardiac remodeling
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