Establish the reference range for homocysteine in middle-aged and elderly individuals in Beijing and analyze the association between homocysteine and uric acid
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摘要: 目的 建立北京地区中老年人群同型半胱氨酸(HCY)的参考区间，并分析其与尿酸(UA)的相关性。方法 筛选在本院体检的2752例50岁以上表观健康中老年人，采用罗氏Cobas c702全自动生化分析仪检测其血清HCY和UA水平，分析不同性别年龄组的HCY水平差异及HCY与UA的相关性，建立适用于本地区中老年人群的HCY参考区间。结果 本研究中2752例表观健康中老年人血清HCY数据呈偏态分布，浓度为11.41(4.62) μmol/L。中老年男性血清HCY水平明显高于女性(Z=20.51，P < 0.05)。血清HCY水平随年龄呈上升趋势：50~59岁组最低：男性11.75(4.00) μmol/L，女性9.36(4.05) μmol/L；80岁以上组最高：男性13.41(6.06) μmol/L，女性10.42(3.98) μmol/L，不同年龄组差异有显著性(P < 0.05)。血清UA和HCY呈正相关(r=0.312，P < 0.05)。血清HCY 95%参考区间按年龄组50~59岁、60~79岁、≥80岁，男性分别为7.63~24.82 μmol/L、7.62~25.71 μmol/L、8.05~29.61 μmol/L；女性分别为5.90~16.14 μmol/L、6.19~18.16 μmol/L、6.04~24.23 μmol/L。结论 初步建立了本地区50岁以上中老年人群血清HCY参考区间，并分析了血清HCY与血清UA的相关性，为中老年人群心脑血管等相关疾病风险预测、诊断治疗提供依据。Abstract: Objective To establish the reference range of homocysteine in middle-aged and elderly individuals in Beijing and to analyze the correlation between homocysteine and uric acid.Methods The 2752 healthy middle-aged and elderly people over 50 years old were selected as reference individuals. Serum HCY and UA levels were measured.Results The data of serum HCY level for 2752 middle-aged and elderly subjects were skewed distribution, and the level was 11.41(4.62)μmol/L. Male participants had higher serum HCY levels than female participants(Z=20.51, P < 0.05). There were significant differences in HCY levels in different age groups(P < 0.05). Serum UA and serum HCY were positively correlated (r=0.312, P < 0.05). The reference ranges of normal serum HCY levels for different age groups(50~59, 60~79, 80~) were 7.63~24.82 μmol/L, 7.62~25.71 μmol/L, and 8.05~29.61 μmol/L, respectively(for males); 5.90~16.14 μmol/L, 6.19~18.16 μmol/L, and 6.04~24.23 μmol/L, respectively(for females).Conclusion This study established preliminary normal serum HCY reference ranges for healthy middle-aged and elderly(>50 years) in this region, which can provide evidence for risk prediction, diagnosis, and treatment of cardiovascular and cerebrovascular diseases in middle-aged and old people.
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Key words:
- homocysteine /
- reference range /
- uric acid /
- middle-aged and elderly
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图 1 中老年人血清HCY水平正态性检验
Figure 1. Normality test of HCY level in middle-aged and elderly people
图 2 不同性别的中老年人HCY水平比较
Figure 2. Comparison of HCY levels in middle-aged and elderly people of different genders
图 3 中老年人血UA和血HCY相关性分析
Figure 3. Correlation analysis of UA and HCY in middle-aged and elderly people
表 1 不同年龄组中老年人血清HCY水平比较
Table 1. Comparison of serum HCY levels in middle-aged and elderly people of different age groups
M(IQR), μmol/L 组别 男性 女性 例数 HCY 例数 HCY 50~59岁 538 11.75(4.00) 162 9.36(4.05) 60~69岁 352 12.60(5.10)1) 284 9.77(3.24)1) 70~79岁 365 12.74(4.80)1) 397 9.84(3.32)1) ≥80岁 399 13.41(6.06)1)2) 255 10.42(3.98)1)2) 合计 1654 12.54(4.81) 1098 9.81(3.55) Z 42.68 21.03 P < 0.001 < 0.001 与50~59岁组比较，1)P < 0.05；与70~79岁组比较，2)P < 0.05。 
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表 2 中老年人血清HCY参考区间
Table 2. Reference ranges of serum HCY in middle-aged and elderly people
μmol/L 组别 性别 例数 M IQR 参考区间 50~59岁 男 538 11.75 4.00 7.63~24.82 女 162 9.36 4.05 5.90~16.14 60~79岁 男 717 12.66 4.99 7.62~25.71 女 681 9.83 3.29 6.19~18.16 ≥80岁 男 399 13.41 6.06 8.05~29.61 女 255 10.42 3.98 6.04~24.23
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