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摘要: 随机临床试验(RCT)结果对心力衰竭(心衰)的病理生理机制提出了挑战，钠-葡萄糖协同转运蛋白-2(SGLT2)抑制剂跨越了神经激素机制对心衰的认识。基于RCT和基础研究证据，本文将探索免疫代谢炎症和心肌细胞信号通路障碍在心衰发病机制中的作用，为心衰防治提供新的靶向治疗方案。Abstract: Recent results of randomized clinical trials (RCT) pose a challenge to the pathophysiology of heart failure(HF). The positive impact of sodium-glucose co-transporter 2(SGLT-2) inhibitors on HF offers new insight into HF beyond the understanding of neurohormonal mechanisms. Based on current evidence from RCTs and basic researches, in this article, we will explore the role of immunometabolic inflammation and dysfunction of the myocardial cell signaling pathway in the pathogenesis of HF, which would provide a new targeted therapy for HF.
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Key words:
- heart failure /
- neurohormonal /
- immunometabolism /
- inflammation /
- cell signaling pathways
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图 1 SGLT2抑制剂治疗慢性心衰的潜在作用机制[5]
Figure 1. The potential mechanism of SGLT2 inhibitors in the treatment of chronic heart failure
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