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摘要: 动脉粥样硬化是一类以脂质过氧化沉积导致血管内皮损伤为主要特征的血管慢性炎症性疾病，并且也是引起冠心病、心力衰竭和脑卒中等心脑血管疾病的重要因素。铁死亡是以铁依赖性脂质过氧化物增加为主要特点的一种新型细胞死亡形式，业已证明可以通过不同的信号途径参与动脉粥样硬化的发生和发展。本文结合前期的资料与研究进一步探讨铁死亡的机制及其相关通路在动脉粥样硬化中发挥的作用，以为临床上防治动脉粥样硬化提供更多的科学依据。Abstract: Atherosclerosis is a chronic vascular inflammatory disease mainly characterized by lipid peroxidation deposition causing vascular endothelial damage, and is an important factor in coronary heart disease, heart failure, stroke and other cardiovascular and cerebrovascular diseases. Ferroptosis is a new form of cell death characterized by the increase of iron-dependent lipid peroxides, which has been shown to be involved in the occurrence and development of AS through different signaling pathways. In this paper, the mechanism of ferroptosis and its role in atherosclerosis were further discussed.
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Key words:
- atherosclerosis /
- ferroptosis /
- lipid peroxides /
- cell death
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