Research progress of heat shock proteins in structural remodeling of atrial fibrillation
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摘要: 心房颤动(atrial fibrillation，AF)是常见的心律失常，具有高致残率和致死率的特征，已成为世界性公共卫生问题，心房结构重构是AF发生发展的关键机制。热休克蛋白(heat shock protein，HSP)是一种分子伴侣蛋白，由一大家族蛋白组成，这些蛋白参与保护机体免受各种形式的细胞应激，它们的经典功能是通过结合部分未折叠的蛋白质来防止异常蛋白质聚集，研究显示，HSP通过抑制心房结构重构，可以预防AF发生并减缓AF的进展。近年来，HSP诱导化合物如替普瑞酮(geranylgeranylacetone，GGA)、L-谷氨酰胺等受到了广泛关注。在这篇综述中，我们概述了HSP在AF结构重构中的保护作用，并讨论了HSP诱导化合物作为AF的新兴治疗药物的研究进展，以期为AF的预防和治疗提供新思路。
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关键词:
- 心房颤动 /
- 热休克蛋白 /
- 结构重构 /
- 热休克蛋白诱导化合物
Abstract: Atrial fibrillation(AF) is a common arrhythmia characterized by high morbidity and mortality, and has become a worldwide public health problem. Atrial structural remodeling is a key mechanism for the occurrence and development of AF. heat shock protein(HSP) is a molecular chaperone protein made up of a large family of proteins that are involved in protecting the body from various forms of cellular stress, and their classic function is to prevent toxic protein aggregation by binding partially folded proteins. HSP plays an important protective role in the occurrence and progression of AF. By preventing atrial remodeling, HSP can prevent the occurrence of AF and prevent the recurrence and progression of AF. In recent years, HSP-inducing compounds such as geranylgeranylacetone(GGA) and L-glutamine have received extensive attention. In this review, we discuss the protective role of HSP in the structural remodeling of AF, and outline the research progress of HSP-inducing compounds as emerging therapeutic agents for AF, with a view to providing new ideas for the prevention and treatment of AF. -
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