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摘要: 几十年来，尽管心力衰竭(心衰)的治疗取得了相当大的进展，但心衰依然是全世界最主要的死亡原因之一。绝大多数能够诱发心衰的心血管疾病受到遗传和环境因素影响，基础及转化研究领域的最新研究进展，如遗传分析和单细胞分析，有助于揭示心衰的发病机制或病理生理机制，有望在心衰的诊断和预后分层方面发挥作用，为开发新的治疗手段提供新的思路和方法。本文主要阐述心衰转化研究方面的最新进展。Abstract: Despite significant progress in the treatment of heart failure over the past few decades, heart failure remains one of the leading causes of death worldwide. Most cardiovascular diseases that predispose individuals to heart failure are caused by genetic and environmental factors. Recent advances in basic and translational research fields, such as genomic analysis and single-cell analysis, has shown great potential for unveiling the pathogenesis and/or pathophysiology, and can contribute to the diagnosis and prognostic stratification of heart failure, which provide new ideas and methods for the development of novel treatment methods. Here, we summarize the recent advances in translational research on heart failure.
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Key words:
- heart failure /
- translational research /
- genomic analysis /
- single-cell analysis
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图 1 心衰诊断及预后分层的转化研究
Figure 1. Translational research on diagnosis and prognostic stratification of heart failure
表 1 近期关于心衰scRNA-seq或snRNA-seq分析的研究
Table 1. Recent studies on scRNA-seq and snRNA-seq analysis in heart failure
小鼠 年份 方法 样本 手术 2017[33] snRNA-seq 左心室CMs 对照组、TAC 2018[15] scRNA-seq 左心室CMs 对照组、TAC 2019[34] scRNA-seq 左心室CMs 对照组、TAC 2019[35] scRNA-seq 整个心脏的CD45+细胞 对照组、TAC 2020[16] scRNA-seq 左心室CMs 对照组、TAC 2020[36] scRNA-seq 左心室CMs 对照组、TAC 2022[17] scRNA-seq 左心室CMs 对照组、TAC、心肌梗死组 人类 年份 方法 样本 患者 2017[33] snRNA-seq 左心室CMs 健康组、扩张型心肌病组 2018[15] scRNA-seq 左心室CMs 健康组、扩张型心肌病组 2020[16] scRNA-seq 左心室CMs 对照组、TAC 2020[37] scRNA-seq 左心室或心房的细胞 健康组、心衰组、部分因植入左心室辅助装置而恢复 2021[38] scRNA-seq、T细胞受体测序 左心室或右心室的细胞 健康组、扩张型心肌病组、缺血性心肌病组 2022[39] scRNA-seq 左心室细胞核 健康组、扩张性型心肌病组、肥厚性心肌病组 2022[17] scRNA-seq 左心室CMs 健康组、扩张型心肌病组 2022[40] snRNA-seq 左心室细胞核 健康组、扩张型心肌病组、致心律失常性心肌病组 2022[41] scRNA-seq、snRNA-seq 左心室CMs 健康组、扩张型心肌病组 TAC：主动脉弓缩窄模型；CMs：心肌细胞。 
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