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摘要: 急性心肌梗死(acute myocardial infarction，AMI)是成年人死亡的主要原因之一，而缺血性脑卒中则是AMI后的严重并发症。目前AMI与缺血性脑卒中发生风险之间的关系仍存在争议。本文拟对AMI合并缺血性脑卒中的发病率、风险因素、病理机制、治疗以及预后进行综述。Abstract: Acute myocardial infarction (AMI) remains a leading cause of adult mortality worldwide, with ischemic stroke representing a significant post-AMI complication. While the association between AMI and subsequent ischemic stroke risk has been extensively studied, the precise nature of this relationship remains controversial. This review comprehensively examines the current evidence regarding post-AMI ischemic stroke, focusing on epidemiology, risk stratification, underlying pathophysiological mechanisms, contemporary therapeutic approaches, and clinical outcomes.
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Key words:
- acute myocardial infarction /
- ischemic stroke /
- treatment strategy
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[1] Al Suwaidi J, Al Habib K, Asaad N, et al. Immediate and one-year outcome of patients presenting with acute coronary syndrome complicated by stroke: findings from the 2nd Gulf Registry of Acute Coronary Events(Gulf RACE-2)[J]. BMC Cardiovasc Disord, 2012, 12: 64. doi: 10.1186/1471-2261-12-64
[2] Ulvenstam A, Kajermo U, Modica A, et al. Incidence, trends, and predictors of ischemic stroke 1 year after an acute myocardial infarction[J]. Stroke, 2014, 45(11): 3263-3268. doi: 10.1161/STROKEAHA.114.005770
[3] Hariri E, Tisminetzky M, Lessard D, et al. Twenty-Five-Year(1986-2011) Trends in the Incidence and Death Rates of Stroke Complicating Acute Myocardial Infarction[J]. Am J Med, 2018, 131(9): 1086-1094. doi: 10.1016/j.amjmed.2018.04.018
[4] Mooe T, Olofsson B O, Stegmayr B, et al. Ischemic stroke. Impact of a recent myocardial infarction[J]. Stroke, 1999, 30(5): 997-1001. doi: 10.1161/01.STR.30.5.997
[5] Brammås A, Jakobsson S, Ulvenstam A, et al. Mortality after ischemic stroke in patients with acute myocardial infarction: predictors and trends over time in Sweden[J]. Stroke, 2013, 44(11): 3050-3055. doi: 10.1161/STROKEAHA.113.001434
[6] Binsell-Gerdin E, Graipe A, Ögren J, et al. Hemorrhagic stroke the first 30days after an acute myocardial infarction: Incidence, time trends and predictors of risk[J]. Int J Cardiol, 2014, 176(1): 133-138. doi: 10.1016/j.ijcard.2014.07.032
[7] Patlolla SH, Sundaragiri PR, Cheungpasitporn W, et al. Intracranial Hemorrhage Complicating Acute Myocardial Infarction: An 18-Year National Study of Temporal Trends, Predictors, and Outcomes[J]. J Clin Med, 2020, 9(9): 2717. doi: 10.3390/jcm9092717
[8] Giugliano RP, Giraldez RR, Morrow DA, et al. Relations between bleeding and outcomes in patients with ST-elevation myocardial infarction in the ExTRACT-TIMI 25 trial[J]. Eur Heart J, 2010, 31(17): 2103-2110. doi: 10.1093/eurheartj/ehq100
[9] Ng PW, Chan WK, Kwan PK. Risk of stroke after acute myocardial infarction among Chinese[J]. Chin Med J, 2001, 114(2): 210-211.
[10] Tsai CF, Thomas B, Sudlow CLM. Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review[J]. Neurology, 2013, 81(3): 264-272. doi: 10.1212/WNL.0b013e31829bfde3
[11] Kajermo U, Ulvenstam A, Modica A, et al. Incidence, Trends, and Predictors of Ischemic Stroke 30 Days After an Acute Myocardial Infarction[J]. Stroke, 2014, 45(5): 1324-1330. doi: 10.1161/STROKEAHA.113.001963
[12] Albaeni A, Harris CM, Nasser H, et al. In-Hospital acute ischemic stroke following ST-elevation myocardial infarction[J]. Int J Cardiol Heart Vasc, 2020, 31: 100684.
[13] Riaz J, Shafique H, Bin Arshad H, et al. Predictors of Ischemic Stroke After Acute Coronary Syndrome: A Retrospective Analysis[J]. Cureus, 2024, 16(9): e68692.
[14] Hurskainen M, Tynkkynen J, Eskola M, et al. Risk Factors for Ischemic Stroke After Acute Coronary Syndrome[J]. J Am Heart Assoc, 2023, 12(14): e028787. doi: 10.1161/JAHA.122.028787
[15] 刘明波, 何新叶, 杨晓红, 等. 《中国心血管健康与疾病报告2023》要点解读[J]. 临床心血管病杂志, 2024, 40(8): 599-616.
[16] Hoang-Anh T, Duong-Minh Q, Nguyen-Thi-Y N, et al. Study of the obstructive sleep apnea syndrome in cerebral infarction patients[J]. Front Neurol, 2023, 14: 1132014. doi: 10.3389/fneur.2023.1132014
[17] Canto JG, Rogers WJ, Goldberg RJ, et al. Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality[J]. JAMA, 2012, 307(8): 813-822.
[18] Stamboul K, Zeller M, Fauchier L, et al. Incidence and prognostic significance of silent atrial fibrillation in acute myocardial infarction[J]. Int J Cardiol, 2014, 174(3): 611-617. doi: 10.1016/j.ijcard.2014.04.158
[19] Fauchier L, Bisson A, Bodin A, et al. Outcomes in patients with acute myocardial infarction and new atrial fibrillation: a nationwide analysis[J]. Clin Res Cardiol, 2021, 110(9): 1431-1438. doi: 10.1007/s00392-021-01805-2
[20] Albaeni A, Chatila K, Beydoun HA, et al. In-hospital left ventricular thrombus following ST-elevation myocardial infarction[J]. Int J Cardiol, 2020, 299: 1-6. doi: 10.1016/j.ijcard.2019.07.070
[21] Maggioni AP, Franzosi MG, Santoro E, et al. The Risk of Stroke in Patients with Acute Myocardial Infarction after Thrombolytic and Antithrombotic Treatment[J]. N Engl J Med, 1992, 327(1): 1-6. doi: 10.1056/NEJM199207023270101
[22] Johannessen KA, Nordrehaug JE, von der Lippe G. Left ventricular thrombosis and cerebrovascular accident in acute myocardial infarction[J]. Br Heart J, 1984, 51(5): 553-556. doi: 10.1136/hrt.51.5.553
[23] Martín R, Bogousslavsky J. Mechanism of late stroke after myocardial infarct: the Lausanne Stroke Registry[J]. J Neurol Neurosurg Psychiatry, 1993, 56(7): 760-764. doi: 10.1136/jnnp.56.7.760
[24] Tanne D, Reicher-Reiss H, Boyko V, et al. Stroke risk after anterior wall acute myocardial infarction. SPRINT Study Group. Secondary Prevention Reinfarction Israeli Nifedipine Trial[J]. Am J Cardiol, 1995, 76(11): 825-826. doi: 10.1016/S0002-9149(99)80236-7
[25] 皮延生, 张薇, 施侣元, 等. 急性心肌梗死住院患者脑卒中危险因素的研究[J]. 中华流行病学杂志, 2002, 23(6): 48-51.
[26] Albaker O, Zubaid M, Alsheikh-Ali AA, et al. Early stroke following acute myocardial infarction: incidence, predictors and outcome in six Middle-Eastern countries[J]. Cerebrovasc Dis, 2011, 32(5): 471-482. doi: 10.1159/000330344
[27] Murakami T, Sakakura K, Jinnouchi H, et al. Acute Ischemic Stroke and Transient Ischemic Attack in ST-Segment Elevation Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention[J]. J Clin Med, 2023, 12(3): 840. doi: 10.3390/jcm12030840
[28] O'Connor CM, Califf M, Massey EW, et al. Strokeand acute Myocardial Infarction in the Thrombolytic era: Clinical correlates and long-term prognosis[J]. J Am Coll Cardiol, 1990, 16(3): 533-540. doi: 10.1016/0735-1097(90)90338-P
[29] Asinger RW, Mikell FL, Elsperger J, et al. Incidence of left-ventricular thrombosis after acute transmural myocardial infarction. Serial evaluation by two-dimensional echocardiography[J]. New Engl J Med, 1981, 305(6): 297-302. doi: 10.1056/NEJM198108063050601
[30] Vaitkus PT, Barnathan ES. Embolic potential, prevention and management of mural thrombus complicating anterior myocardial infarction: a meta-analysis[J]. J Am Coll Cardiol, 1993, 22(4): 1004-1009. doi: 10.1016/0735-1097(93)90409-T
[31] Delewi R, Zijlstra F, Piek JJ. Left ventricular thrombus formation after acute myocardial infarction[J]. Heart, 2012, 98(23): 1743-1749. doi: 10.1136/heartjnl-2012-301962
[32] Putaala J, Nieminen T. Stroke Risk Period After Acute Myocardial Infarction Revised[J]. J Am Heart Assoc, 2018, 7(22): e011200. doi: 10.1161/JAHA.118.011200
[33] Tanne D, Goldbourt U, Zion M, et al. Frequency and prognosis of stroke/TIA among 4808 survivors of acute myocardial infarction. The SPRINT Study Group[J]. Stroke, 1993, 24(10): 1490-1495. doi: 10.1161/01.STR.24.10.1490
[34] Kijpaisalratana N, Chutinet A, Suwanwela NC. Hyperacute Simultaneous Cardiocerebral Infarction: Rescuing the Brain or the Heart First?[J]. Front Neurol, 2017, 8: 664. doi: 10.3389/fneur.2017.00664
[35] Bodenheimer MM, Sauer D, Shareef B, et al. Relation between myocardial infarct location and stroke[J]. J Am Coll Cardiol, 1994, 24(1): 61-66. doi: 10.1016/0735-1097(94)90542-8
[36] Udell JA, Wang JT, Gladstone DJ, et al. Anticoagulation after Anterior Myocardial Infarction and the Risk of Stroke[J]. PLoS One, 2010, 5(8): e12150. doi: 10.1371/journal.pone.0012150
[37] 邢靖贤, 袁永刚, 耿涛. 不同时间窗冠状动脉介入治疗对急性心肌梗死患者心功能及脑卒中发生情况的影响[J]. 临床心血管病杂志, 2021, 37(8): 710-714.
[38] Shi B, Ma X, Ye C, et al. Timing of percutaneous coronary intervention and risk of new-onset acute ischemic stroke in non-ST elevation myocardial infarction: A retrospective cohort study insight into the National Inpatient Sample Database(2016-2019)[J]. Health Sci Rep, 2024, 7(9): e70029. doi: 10.1002/hsr2.70029
[39] Bay B, Goẞling A, Remmel M, et al. Temporal trends and outcomes of acute ischaemic strokes in patients hospitalised for percutaneous coronary intervention[J]. EuroIntervention, 2024, 20(17): e1098-e1106. doi: 10.4244/EIJ-D-24-00189
[40] Alkhouli M, Alqahtani F, Tarabishy A, et al. Incidence, Predictors, and Outcomes of Acute Ischemic Stroke Following Percutaneous Coronary Intervention[J]. JACC Cardiovasc Interv, 2019, 12(15): 1497-1506. doi: 10.1016/j.jcin.2019.04.015
[41] Kwok CS, Kontopantelis E, Myint PK, et al. Stroke following percutaneous coronary intervention: type-specific incidence, outcomes and determinants seen by the British Cardiovascular Intervention Society 2007-12[J]. Eur Heart J, 2015, 36(25): 1618-1628. doi: 10.1093/eurheartj/ehv113
[42] Heusch G, Gersh BJ. The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge[J]. Eur Heart J, 2017, 38(11): 774-784.
[43] Alkarithi G, Duval C, Shi Y, et al. Thrombus Structural Composition in Cardiovascular Disease[J]. Arterioscler Thromb Vasc Biol, 2021, 41(9): 2370-2383. doi: 10.1161/ATVBAHA.120.315754
[44] George PM, Steinberg GK. Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments[J]. Neuron, 2015, 87(2): 297-309. doi: 10.1016/j.neuron.2015.05.041
[45] Camaj A, Fuster V, Giustino G, et al. Left Ventricular Thrombus Following Acute Myocardial Infarction: JACC State-of-the-Art Review[J]. J Am Coll Cardiol, 2022, 79(10): 1010-1022. doi: 10.1016/j.jacc.2022.01.011
[46] Gianstefani S, Douiri A, Delithanasis I, et al. Incidence and predictors of early left ventricular thrombus after ST-elevation myocardial infarction in the contemporary era of primary percutaneous coronary intervention[J]. Am J Cardiol, 2014, 113(7): 1111-1116. doi: 10.1016/j.amjcard.2013.12.015
[47] Zhang P, Ge X, Li Z, et al. The prognostic role of cardiac rehabilitation in patients with left ventriCular aneurysm formation after anterior myocardial infarction(the GRACE study): Study rationale and design of a prospective randomized controlled trial[J]. Front Cardiovasc Med, 2023, 9: 991521. doi: 10.3389/fcvm.2022.991521
[48] Wybraniec M, Mizia-Szubryt M, Gawalko M, et al. Heart failure and the risk of left atrial thrombus formation in patients with atrial fibrillation and atrial flutter: insights from the LATTEE registry[J]. Eur Heart J, 2022, 43(Supplement_2): ehac544.622. doi: 10.1093/eurheartj/ehac544.622
[49] 杨丽. 急性心肌梗死患者PCI术后并发急性脑梗死的发生率及危险因素分析[J]. 中国实用神经疾病杂志, 2017, 20(3): 99-101.
[50] 刘华, 芮晨, 杨炳健. 急性心肌梗死PCI术后患者急性脑梗死的发生率及其Logistic回归分析[C]//全国科研理论学术研究成果汇编. 中国环球文化出版社、华教创新(北京)文化传媒有限公司, 2020: 4.
[51] Bhandari M, Vishwakarma P, Sethi R, et al. Stroke Complicating Acute ST Elevation Myocardial Infarction-Current Concepts[J]. Int J Angiol, 2019, 28(4): 226-230. doi: 10.1055/s-0039-1695049
[52] Head SJ, Börgermann J, Osnabrugge RLJ, et al. Coronary artery bypass grafting: Part 2--optimizing outcomes and future prospects[J]. Eur Heart J, 2013, 34(37): 2873-2886. doi: 10.1093/eurheartj/eht284
[53] Gaudino M, Angiolillo DJ, Di Franco A, et al. Stroke After Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention: Incidence, Pathogenesis, and Outcomes[J]. J Am Heart Assoc, 2019, 8(13): e013032. doi: 10.1161/JAHA.119.013032
[54] Laimoud M, Maghirang M, Alanazi M, et al. Predictors and clinical outcomes of post-coronary artery bypass grafting cerebrovascular strokes[J]. Egypt Heart J, 2022, 74(1): 76. doi: 10.1186/s43044-022-00315-4
[55] Boyanpally A, Cutting S, Furie K. Acute Ischemic stroke associated with myocardial Infarction: Challenges and management[J]. Semin Neurol, 2021, 41(4): 331-339. doi: 10.1055/s-0041-1726333
[56] Warner JJ, Harrington RA, Sacco RL, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke[J]. Stroke, 2019, 50(12): 3331-3332. doi: 10.1161/STROKEAHA.119.027708
[57] Demaerschalk BM, Kleindorfer DO, Adeoye OM, et al. Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association[J]. Stroke, 2016, 47(2): 581-641. doi: 10.1161/STR.0000000000000086
[58] 马丽苹, 矫树生, 王晓鹏. 尤瑞克林联合丁苯酞治疗老老年急性脑梗死的临床疗效研究[J]. 重庆医学, 2023, 52(20): 3088-3092.
[59] 杨俊山. 尤瑞克林治疗急性脑梗死的药理分析及对神经功能的影响[J]. 中国现代药物应用, 2020, 14(24): 145-147.
[60] Wang TJ, Wu ZY, Yang CH, et al. Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway[J]. Am J Chin Med, 2022, 50(6): 1565-1597. doi: 10.1142/S0192415X22500665
[61] Xu J, Wang A, Meng X, et al. Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke: A Phase Ⅲ, Randomized, Double-Blind, Comparative Trial[J]. Stroke, 2021, 52(3): 772-780. doi: 10.1161/STROKEAHA.120.031197
[62] 刘颖丽, 杨立彬, 张舒石, 等. 丁苯酞注射液治疗老年急性脑梗死患者的疗效及其对脑血流动力和脑血管储备能力的影响[J]. 吉林大学学报(医学版), 2017, 43(2): 344-348.
[63] 赵海燕, 李源, 欧阳辉, 等. 依达拉奉联合瑞舒伐他汀治疗心源性脑梗死的疗效及对血清CXCL12、UCH-L1、HC-gp39水平的影响[J]. 中国现代医学杂志, 2023, 33(10): 23-27.
[64] 宋元清, 马进, 李钢. 银杏二萜内酯葡胺联合丁苯酞对急性心源性脑卒中患者神经功能及血液流变学的影响[J]. 药品评价, 2021, 18(14): 891-893.
[65] Park HK, Lee JS, Hong KS, et al. Statin therapy in acute cardioembolic stroke with no guidance-based indication[J]. Neurology, 2020, 94(19): e1984-e1995. http://www.xueshufan.com/publication/3015533087
[66] Chai-Adisaksopha C, Hillis CM, Witt DM, et al. Warfarin Resumption after Intracranial Hemorrhage: A Systematic Review and Meta-Analysis[J]. Blood, 2016, 128(22): 3821-3821. doi: 10.1182/blood.V128.22.3821.3821
[67] 陈锐. 冠状动脉支架置入术后1年患者药物治疗依从性及其相关影响因素研究[D]. 吉林大学, 2019.
[68] Xu Y, Chen A, Wu J, et al. Nanomedicine: An Emerging Novel Therapeutic Strategy for Hemorrhagic Stroke[J]. Int J Nanomedicine, 2022, 17: 1927-1950. doi: 10.2147/IJN.S357598
[69] Zenych A, Fournier L, Chauvierre C. Nanomedicine progress in thrombolytic therapy[J]. Biomaterials, 2020, 258: 120297. doi: 10.1016/j.biomaterials.2020.120297
[70] Widimsky P, Coram R, Abou-Chebl A. Reperfusion therapy of acute ischaemic stroke and acute myocardial infarction: similarities and differences[J]. Eur Heart J, 2014, 35(3): 147-155. doi: 10.1093/eurheartj/eht409
[71] Yeo LLL, Andersson T, Yee KW, et al. Synchronous cardiocerebral infarction in the era of endovascular therapy: which to treat first?[J]. J Thromb Thrombolysis, 2017, 44(1): 104-111. doi: 10.1007/s11239-017-1484-2
[72] Berge E, Whiteley W, Audebert H, et al. European Stroke Organisation(ESO)guidelines on intravenous thrombolysis for acute ischaemic stroke[J]. Eur Stroke J, 2021, 6(1): I-LXⅡ. doi: 10.1177/2396987321989865
[73] Zaidat OO, Ikeme S, Sheth SA, et al. MASTRO I: Meta-Analysis and Systematic Review of thrombectomy stent retriever outcomes: comparing functional, safety and recanalization outcomes between EmboTrap, Solitaire and Trevo in acute ischemic stroke[J]. J Comp Eff Res, 2023, 12(5): e230001. doi: 10.57264/cer-2023-0001
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